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3C-E (3,5-Dimethoxy-4-ethoxyamphetamine) is a psychedelic of the amphetamine class. It was first synthesized by Alexander Shulgin. In his book PiHKAL, Shulgin lists the dosage range as 30 to 60 mg, consumed orally.<ref name="PiHKAL">PiHKAL entry</ref><ref name="HalberstadtChathaKlein2020">Template:Cite journal</ref> The duration of action was stated to be 8–12 hours.<ref name=PiHKAL/>

This compound is the amphetamine analog of escaline.

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