Cephamycin

File:Cephamycin core structure.svg

Core structure of the cephamycins.

Cephamycins are a group of β-lactam antibiotics. They are very similar to cephalosporins, and the cephamycins are sometimes classified as cephalosporins.

Like cephalosporins, cephamycins are based upon the cephem nucleus. Unlike most cephalosporins, cephamycins are a very efficient antibiotic against anaerobic microbes.Template:Cn

Cephamycins were originally produced by Streptomyces, but synthetic ones have been produced as well.Template:Cn

Cephamycins possess a methoxy group at the 7-alpha position.<ref name="isbn1-55581-258-9">Template:Cite book</ref>

In addition, cephamycins have been shown to be stable against extended-spectrum beta-lactamase (ESBL) producing organisms, although their use in clinical practice is lacking for this indication.Template:Cn

Examples

Cephamycins include:

• Cefoxitin<ref name="pmid279853">Template:Cite journal</ref>
• Cefotetan<ref name="pmid6404881">Template:Cite journal</ref>
• Cefmetazole<ref name="pmid6958672">Template:Cite journal</ref>

References

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