Template:Short description Template:Infobox anatomy
The ependyma is the thin neuroepithelial (simple columnar ciliated epithelium) lining of the ventricular system of the brain and the central canal of the spinal cord.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> The ependyma is one of the four types of neuroglia in the central nervous system (CNS). It is involved in the production of cerebrospinal fluid (CSF), and is shown to serve as a reservoir for neuroregeneration.
StructureEdit
The ependyma is made up of ependymal cells called ependymocytes, a type of glial cell. These cells line the ventricles in the brain and the central canal of the spinal cord, which become filled with cerebrospinal fluid. These are nervous tissue cells with simple columnar shape, much like that of some mucosal epithelial cells.<ref>Histology, a text in atlas, M. Ross 2011, 6th edition page 367</ref> Early monociliated ependymal cells are differentiated to multiciliated ependymal cells for their function in circulating cerebrospinal fluid.<ref name="Kyrousi">Template:Cite journal</ref>
The basal membranes of these cells are characterized by tentacle-like extensions that attach to astrocytes. The apical side is covered in cilia and microvilli.<ref name=":0">Template:Citation</ref>
FunctionEdit
Cerebrospinal fluidEdit
Lining the CSF-filled ventricles, and spinal canal, the ependymal cells play an important role in the production and regulation of CSF. Their apical surfaces are covered in a layer of cilia, which circulate CSF around the CNS.<ref name=":0" /> Their apical surfaces are also covered with microvilli, which absorb CSF. Within the ventricles of the brain, a population of modified ependymal cells and capillaries together known as the tela choroidea form a structure called the choroid plexus, which produces the CSF.<ref name="Langmans">Template:Cite book</ref>
Modified tight junctions between epithelial cells control fluid release. This release allows free exchange between CSF and nervous tissue of brain and spinal cord. This is why sampling of CSF, such as through a spinal tap, provides information about the whole CNS.
NeuroregenerationEdit
Jonas Frisén and his colleagues at the Karolinska Institute in Stockholm provided evidence that ependymal cells act as reservoir cells in the forebrain, which can be activated after stroke and as in vivo and in vitro stem cells in the spinal cord. However, these cells did not self-renew and were subsequently depleted as they generated new neurons, thus failing to satisfy the requirement for stem cells.<ref>Template:Cite journal</ref><ref>Template:Cite journal</ref> One study observed that ependymal cells from the lining of the lateral ventricle might be a source for cells which can be transplanted into the cochlea to reverse hearing loss.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>
Clinical significanceEdit
Ependymoma is a tumor of the ependymal cells most commonly found in the fourth ventricle.