Gemfibrozil

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Gemfibrozil, sold under the brand name Lopid among others, is a medication used to treat abnormal blood lipid levels.<ref name=AHFS2019/> It is generally less preferred than statins.<ref name=AHFS2019/><ref name=BNF76/> Use is recommended together with dietary changes and exercise.<ref name=AHFS2019/> It is unclear if it changes the risk of heart disease.<ref name=AHFS2019/> It is taken by mouth.<ref name=AHFS2019/>

Common side effects include headache, dizziness, feeling tired, and intestinal upset.<ref name=AHFS2019/> Serious side effects may include angioedema, gallstones, liver problems, and muscle breakdown.<ref name=AHFS2019/> Use in pregnancy and breastfeeding is of unclear safety.<ref name=Preg2019>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> It belongs to the fibrates group of medications and works by decreasing the breakdown of lipids in fat cells.<ref name=AHFS2019>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

Gemfibrozil was patented in 1968, and came into medical use in 1982.<ref name=Fis2006>Template:Cite book</ref> It is available as a generic medication.<ref name=BNF76>Template:Cite book</ref> In 2022, it was the 231st most commonly prescribed medication in the United States, with more than 1Template:Nbspmillion prescriptions.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref><ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

Medical uses

• Hyperlipidemia (Type III)
• Hypertriglyceridemia (Type IV): Gemfibrozil, though not as effective as niacin (nicotinic acid, a form of Vitamin B3), is better tolerated.Template:Citation needed
• Reduce triglyceride levels <ref>{{#invoke:citation/CS1|citation

|CitationClass=web }}</ref>

• Reduce very low density lipoprotein (VLDL) levels
• Modest reduction of low density lipoprotein (LDL) levels
• Moderate increase in high density lipoprotein (HDL) levels

Side effects

• GI distress
• Musculoskeletal pain
• Increased incidence of gallstone
• Hypokalemia (low blood potassium)
• Increased risk of cancer

Contraindications

• Gemfibrozil should not be given to these patients:Template:Citation needed
  • Hepatic dysfunction
• Gemfibrozil should be used with caution in these higher risk categories:Template:Citation needed
  • Biliary tract disease
  • Renal dysfunction
  • Pregnant women
  • Obese patients

Drug interactions

• Anticoagulants: Gemfibrozil potentiates the action of warfarin and indanedione anticoagulants.Template:Citation needed
• Statin drugs: Concomitant administration of fibrates (including gemfibrozil) with statin drugs increases the risk of muscle cramping, myopathy, and rhabdomyolysis.<ref>{{#invoke:citation/CS1|citation

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• Gemfibrozil inhibits the activation of the liver's Cytochrome P450 system and CYP2C8, reducing hepatic metabolism of many drugs, and prolonging their half lives and duration of action.
  • Drugs metabolized by the Cytochrome P450 system include:
    • Many antidepressants
    • Many antipsychotics
    • Many antiepileptics
    • Theophylline and other methylxanthine drugs
    • Several anesthetic agents
    • Oral contraceptive pills
    • Statins
    • Warfarin
    • Selexipag

Mechanism of actions

The exact mechanism of action of gemfibrozil is unknown; however, several theories exist regarding the very low density lipoprotein (VLDL) effect; it can inhibit lipolysis and decrease subsequent hepatic fatty acid uptake as well as inhibit hepatic secretion of VLDL; together these actions decrease serum VLDL levels and increase HDL-cholesterol; the mechanism behind HDL elevation is currently unknown.

Gemfibrozil increases the activity of extrahepatic lipoprotein lipase (LL), thereby increasing lipoprotein triglyceride lipolysis. It does so by activating peroxisome proliferator-activated receptor alpha (PPARα) 'transcription factor ligand', a receptor that is involved in metabolism of carbohydrates and fats, as well as adipose tissue differentiation. This increase in the synthesis of lipoprotein lipase thereby increases the clearance of triglycerides. Chylomicrons are degraded, VLDLs are converted to LDLs, and LDLs are converted to HDL. This is accompanied by a slight increase in secretion of lipids into the bile and ultimately the intestine. Gemfibrozil also inhibits the synthesis and increases the clearance of apolipoprotein B, a carrier molecule for VLDL.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

History

Gemfibrozil was selected from a series of related compounds synthesized in the laboratories of the American company Parke-Davis in the late 1970s. It came from research for compounds that lower plasma lipid levels in humans and in animals.<ref>Template:Cite journal</ref>

Environmental data

Gemfibrozil has been detected in biosolids (the solids remaining after sewage treatment) at concentrations up to 2650 ng/g wet weight.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> This indicates that it survives the wastewater treatment process. It is also detected as environmental persistent micropollutant in aquifers and in groundwaters in karstic areas.<ref>Template:Cite journal</ref>

Further reading

• Template:Cite journal
• Template:Cite book

External links

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