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Poliomyelitis (Template:IPAc-en Template:Respell), commonly shortened to polio, is an infectious disease caused by the poliovirus.<ref name="PinkBook2021" /> Approximately 75% of cases are asymptomatic;<ref name="ECDC">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> mild symptoms which can occur include sore throat and fever; in a proportion of cases more severe symptoms develop such as headache, neck stiffness, and paresthesia.<ref name="PinkBook2021" /><ref name="WHO2014" /> These symptoms usually pass within one or two weeks. A less common symptom is permanent paralysis, and possible death in extreme cases.<ref name="PinkBook2021">Template:Cite book.</ref> Years after recovery, post-polio syndrome may occur, with a slow development of muscle weakness similar to what the person had during the initial infection.<ref name="NIH2014Post">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>
Polio occurs naturally only in humans.<ref name="PinkBook2021" /> It is highly infectious, and is spread from person to person either through fecal–oral transmission<ref name="PinkBook2021" /><ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> (e.g. poor hygiene, or by ingestion of food or water contaminated by human feces), or via the oral–oral route. Those who are infected may spread the disease for up to six weeks even if no symptoms are present. The disease may be diagnosed by finding the virus in the feces or detecting antibodies against it in the blood.<ref name="PinkBook2021" />
Poliomyelitis has existed for thousands of years, with depictions of the disease in ancient art.<ref name="PinkBook2021" /> The disease was first recognized as a distinct condition by the English physician Michael Underwood in 1789,<ref name="PinkBook2021" /><ref>Template:Cite book</ref> and the virus that causes it was first identified in 1909 by the Austrian immunologist Karl Landsteiner.<ref>Template:Cite book</ref><ref>Template:Cite journal</ref> Major outbreaks started to occur in the late 19th century in Europe and the United States,<ref name="PinkBook2021" /> and in the 20th century, it became one of the most worrying childhood diseases.<ref>Template:Cite book</ref> Following the introduction of polio vaccines in the 1950s, polio incidence declined rapidly.<ref name="PinkBook2021" /> Template:As of, only Pakistan and Afghanistan remain endemic for wild poliovirus (WPV).<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>
Once infected, there is no specific treatment.<ref name="WHO2014" /> The disease can be prevented by the polio vaccine, with multiple doses required for lifelong protection.<ref name="WHO2014" /> There are two broad types of polio vaccine; an injected polio vaccine (IPV) using inactivated poliovirus and an oral polio vaccine (OPV) containing attenuated (weakened) live virus.<ref name="PinkBook2021" /> Through the use of both types of vaccine, incidence of wild polio has decreased from an estimated 350,000 cases in 1988<ref name="WHO2014">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> to 30 confirmed cases in 2022, confined to just three countries.<ref name="GPEI2022-05">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> In rare cases, the traditional OPV was able to revert to a virulent form. An improved oral vaccine with greater genetic stability (nOPV2) was developed and granted full licensure and prequalification by the World Health Organization in December 2023.<ref name="www.cdc.gov2022">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref><ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>
Signs and symptomsEdit
| Outcome | Proportion of cases<ref name = PinkBook2021/> |
|---|---|
| No symptoms | 72% |
| Minor illness | 24% |
| Nonparalytic aseptic meningitis |
1–5% |
| Paralytic poliomyelitis | 0.1–0.5% |
| — Spinal polio | 79% of paralytic cases |
| — Bulbospinal polio | 19% of paralytic cases |
| — Bulbar polio | 2% of paralytic cases |
The term "poliomyelitis" is used to identify the disease caused by any of the three serotypes of poliovirus. Two basic patterns of polio infection are described: a minor illness that does not involve the central nervous system (CNS), sometimes called abortive poliomyelitis, and a major illness involving the CNS, which may be paralytic or nonparalytic.<ref>Template:Cite journal</ref> Adults are more likely to develop symptoms, including severe symptoms, than children.<ref name="PinkBook2021" />
In most people with a normal immune system, a poliovirus infection is asymptomatic. In about 25% of cases, the infection produces minor symptoms which may include sore throat and low fever.<ref name="WHO2014" /><ref name="ECDC" /> These symptoms are temporary and full recovery occurs within one or two weeks.<ref name="PinkBook2021" /><ref name="WHO2014" />
In about 1 percent of infections the virus can migrate from the gastrointestinal tract into the central nervous system (CNS).<ref name="PinkBook2021" /> Most patients with CNS involvement develop nonparalytic aseptic meningitis, with symptoms of headache, neck, back, abdominal and extremity pain, fever, vomiting, stomach pain, lethargy, and irritability.<ref name="Chamberlin_2005">Template:Cite book</ref><ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref><ref name="Late">Template:Cite book</ref> About one to five in 1,000 cases progress to paralytic disease, in which the muscles become weak, floppy and poorly controlled, and, finally, completely paralyzed; this condition is known as acute flaccid paralysis.<ref name="Henry1" /> The weakness most often involves the legs, but may less commonly involve the muscles of the head, neck, and diaphragm.<ref name="PinkBook2021" /> Depending on the site of paralysis, paralytic poliomyelitis is classified as spinal, bulbar, or bulbospinal. In those who develop paralysis, between 2 and 10 percent die as the paralysis affects the breathing muscles.<ref name="WHO2014" />
Encephalitis, an infection of the brain tissue itself, can occur in rare cases, and is usually restricted to infants. It is characterized by confusion, changes in mental status, headaches, fever, and, less commonly, seizures and spastic paralysis.<ref name="Encephalitis">Template:Cite book</ref>
EtymologyEdit
The term poliomyelitis derives from the Ancient Greek Template:Transliteration ({{#invoke:Lang|lang}}), meaning "grey", Template:Transliteration ({{#invoke:Lang|lang}} "marrow"), referring to the grey matter of the spinal cord, and the suffix -itis, which denotes inflammation,<ref name="Chamberlin_2005" /> i.e., inflammation of the spinal cord's grey matter. The word was first used in 1874 and is attributed to the German physician Adolf Kussmaul.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> The first recorded use of the abbreviated version polio was in the Indianapolis Star in 1911.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>
CauseEdit
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Poliomyelitis does not affect any species other than humans.<ref name="Sherris">Template:Cite book</ref> The disease is caused by infection with a member of the genus Enterovirus known as poliovirus (PV). This group of RNA viruses colonize the gastrointestinal tract<ref name=Harrison>Template:Cite book</ref> – specifically the oropharynx and the intestine. Its structure is quite simple, composed of a single (+) sense RNA genome enclosed in a protein shell called a capsid.<ref name=Sherris /> In addition to protecting the virus' genetic material, the capsid proteins enable poliovirus to infect certain types of cells. Three serotypes of poliovirus have been identified – wild poliovirus type 1 (WPV1), type 2 (WPV2), and type 3 (WPV3) – each with a slightly different capsid protein.<ref>Template:Cite book</ref> All three are extremely virulent and produce the same disease symptoms.<ref name=Sherris /> WPV1 is the most commonly encountered form, and the one most closely associated with paralysis.<ref name="Ohri">Template:Cite journal (Available free on Medscape; registration required.)</ref> WPV2 was certified as eradicated in 2015 and WPV3 certified as eradicated in 2019.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>
The incubation period (from exposure to the first signs and symptoms) ranges from three to six days for nonparalytic polio. If the disease progresses to cause paralysis, this occurs within 7 to 21 days.<ref name="PinkBook2021" />
Individuals who are exposed to the virus, either through infection or by immunization via polio vaccine, develop immunity. In immune individuals, IgA antibodies against poliovirus are present in the tonsils and gastrointestinal tract and able to block virus replication; IgG and IgM antibodies against PV can prevent the spread of the virus to motor neurons of the central nervous system.<ref name="Kew_2005">Template:Cite journal</ref> Infection or vaccination with one serotype of poliovirus does not provide immunity against the other serotypes, and full immunity requires exposure to each serotype.<ref name=Kew_2005/>
A rare condition with a similar presentation, nonpoliovirus poliomyelitis, may result from infections with enteroviruses other than poliovirus.<ref>Template:Cite journal</ref>
The oral polio vaccine, which has been in use since 1961,<ref name="WHO2016">Template:Cite journal</ref> contains weakened viruses that can replicate. On rare occasions, these may be transmitted from the vaccinated person to other people; in communities with good vaccine coverage, transmission is limited, and the virus dies out. In communities with low vaccine coverage, this weakened virus may continue to circulate and, over time may mutate and revert to a virulent form.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> Polio arising from this cause is referred to as circulating vaccine-derived poliovirus (cVDPV) or variant poliovirus in order to distinguish it from the natural or "wild" poliovirus (WPV).<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>
TransmissionEdit
Poliomyelitis is highly contagious. The disease is transmitted primarily via the fecal–oral route, by ingesting contaminated food or water. It is occasionally transmitted via the oral–oral route.<ref name="PinkBook2021" /> It is seasonal in temperate climates, with peak transmission occurring in summer and autumn. These seasonal differences are far less pronounced in tropical areas.<ref name="Kew_2005" /> Polio is most infectious between 7 and 10 days before and after the appearance of symptoms, but transmission is possible as long as the virus remains in the saliva or feces. Virus particles can be excreted in the feces for up to six weeks.<ref name="ECDC" />
Factors that increase the risk of polio infection include pregnancy,<ref name="Evans_1960">Template:Cite journal</ref> being very old or very young, immune deficiency,<ref>Template:Citation</ref> and malnutrition.<ref>Template:Cite journal</ref> Although the virus can cross the maternal-fetal barrier during pregnancy, the fetus does not appear to be affected by either maternal infection or polio vaccination.<ref name=UK>Template:Cite book</ref> Maternal antibodies also cross the placenta, providing passive immunity that protects the infant from polio infection during the first few months of life.<ref>Template:Cite journal</ref>
PathophysiologyEdit
Poliovirus enters the body through the mouth, infecting the first cells with which it comes in contact – the pharynx and intestinal mucosa. It gains entry by binding to an immunoglobulin-like receptor, known as the poliovirus receptor or CD155, on the cell membrane.<ref name=He>Template:Cite journal</ref> The virus then hijacks the host cell's own machinery, and begins to replicate. Poliovirus divides within gastrointestinal cells for about a week, from where it spreads to the tonsils (specifically the follicular dendritic cells residing within the tonsilar germinal centers), the intestinal lymphoid tissue including the M cells of Peyer's patches, and the deep cervical and mesenteric lymph nodes, where it multiplies abundantly. The virus is subsequently absorbed into the bloodstream.<ref name=Baron>Template:Cite book</ref>
Known as viremia, the presence of a virus in the bloodstream enables it to be widely distributed throughout the body. Poliovirus can survive and multiply within the blood and lymphatics for long periods of time, sometimes as long as 17 weeks.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> In a small percentage of cases, it can spread and replicate in other sites, such as brown fat, the reticuloendothelial tissues, and muscle.<ref>Template:Cite journal</ref> This sustained replication causes a major viremia, and leads to the development of minor influenza-like symptoms. Rarely, this may progress and the virus may invade the central nervous system, provoking a local inflammatory response. In most cases, this causes a self-limiting inflammation of the meninges, the layers of tissue surrounding the brain, which is known as nonparalytic aseptic meningitis.<ref name=Chamberlin_2005 /> Penetration of the CNS provides no known benefit to the virus, and is quite possibly an incidental deviation of a normal gastrointestinal infection.<ref name= Mueller>Template:Cite journal</ref> The mechanisms by which poliovirus spreads to the CNS are poorly understood, but it appears to be primarily a chance event – largely independent of the age, gender, or socioeconomic position of the individual.<ref name=Mueller />
Paralytic polioEdit
In around one percent of infections, poliovirus spreads along certain nerve fiber pathways, preferentially replicating in and destroying motor neurons within the spinal cord, brain stem, or motor cortex. This leads to the development of paralytic poliomyelitis, the various forms of which (spinal, bulbar, and bulbospinal) vary only with the amount of neuronal damage and inflammation that occurs, and the region of the CNS affected.<ref>Template:Cite journal</ref>
The destruction of neuronal cells produces lesions within the spinal ganglia; these may also occur in the reticular formation, vestibular nuclei, cerebellar vermis, and deep cerebellar nuclei.<ref name=Mueller /> Inflammation associated with nerve cell destruction often alters the color and appearance of the gray matter in the spinal column, causing it to appear reddish and swollen.<ref name=Chamberlin_2005/> Other destructive changes associated with paralytic disease occur in the forebrain region, specifically the hypothalamus and thalamus.<ref name=Mueller />
Early symptoms of paralytic polio include high fever, headache, stiffness in the back and neck, asymmetrical weakness of various muscles, sensitivity to touch, difficulty swallowing, muscle pain, loss of superficial and deep reflexes, paresthesia (pins and needles), irritability, constipation, or difficulty urinating. Paralysis generally develops one to ten days after early symptoms begin, progresses for two to three days, and is usually complete by the time the fever breaks.<ref name= Silverstein>Template:Cite book</ref>
The likelihood of developing paralytic polio increases with age, as does the extent of paralysis. In children, nonparalytic meningitis is the most likely consequence of CNS involvement, and paralysis occurs in only one in 1000 cases. In adults, paralysis occurs in one in 75 cases.<ref name="Gawne_1995">Template:Cite journal Reproduced online with permission by Lincolnshire Post-Polio Library; retrieved on 10 November 2007.</ref> In children under five years of age, paralysis of one leg is most common; in adults, extensive paralysis of the chest and abdomen also affecting all four limbs – quadriplegia – is more likely.<ref name=Young>Template:Cite journal</ref> Paralysis rates also vary depending on the serotype of the infecting poliovirus; the highest rates of paralysis (one in 200) are associated with poliovirus type 1, the lowest rates (one in 2,000) are associated with type 2.<ref name=Nathanson>Template:Cite journal</ref>
Spinal polioEdit
Spinal polio, the most common form of paralytic poliomyelitis, results from viral invasion of the motor neurons of the anterior horn cells, or the ventral (front) grey matter section in the spinal column, which are responsible for movement of the muscles, including those of the trunk, limbs, and the intercostal muscles.<ref name= Henry1>Template:Cite book</ref> Virus invasion causes inflammation of the nerve cells, leading to damage or destruction of motor neuron ganglia. When spinal neurons die, Wallerian degeneration takes place, leading to weakness of those muscles formerly innervated by the now-dead neurons.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> With the destruction of nerve cells, the muscles no longer receive signals from the brain or spinal cord; without nerve stimulation, the muscles atrophy, becoming weak, floppy and poorly controlled, and finally completely paralyzed.<ref name=Henry1 /> Maximum paralysis progresses rapidly (two to four days), and usually involves fever and muscle pain. Deep tendon reflexes are also affected, and are typically absent or diminished; sensation (the ability to feel) in the paralyzed limbs, however, is not affected.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>
The extent of spinal paralysis depends on the region of the cord affected, which may be cervical, thoracic, or lumbar.<ref name=Guide>Template:Cite book</ref> The virus may affect muscles on both sides of the body, but more often the paralysis is asymmetrical.<ref name=Baron /> Any limb or combination of limbs may be affected – one leg, one arm, or both legs and both arms. Paralysis is often more severe proximally (where the limb joins the body) than distally (the fingertips and toes).<ref name=Baron />
Bulbar polioEdit
Making up about two percent of cases of paralytic polio, bulbar polio occurs when poliovirus invades and destroys nerves within the bulbar region of the brain stem.<ref name = PinkBook2021 /> The bulbar region is a white matter pathway that connects the cerebral cortex to the brain stem. The destruction of these nerves weakens the muscles supplied by the cranial nerves, producing symptoms of encephalitis, and causes difficulty breathing, speaking and swallowing.<ref name=Late /> Critical nerves affected are the glossopharyngeal nerve (which partially controls swallowing and functions in the throat, tongue movement, and taste), the vagus nerve (which sends signals to the heart, intestines, and lungs), and the accessory nerve (which controls upper neck movement). Due to the effect on swallowing, secretions of mucus may build up in the airway, causing suffocation.<ref name = Silverstein /> Other signs and symptoms include facial weakness (caused by destruction of the trigeminal nerve and facial nerve, which innervate the cheeks, tear ducts, gums, and muscles of the face, among other structures), double vision, difficulty in chewing, and abnormal respiratory rate, depth, and rhythm (which may lead to respiratory arrest). Pulmonary edema and shock are also possible and may be fatal.<ref name=Guide/>
Bulbospinal polioEdit
Approximately 19 percent of all paralytic polio cases have both bulbar and spinal symptoms; this subtype is called respiratory or bulbospinal polio.<ref name=PinkBook2021 /> Here, the virus affects the upper part of the cervical spinal cord (cervical vertebrae C3 through C5), and paralysis of the diaphragm occurs. The critical nerves affected are the phrenic nerve (which drives the diaphragm to inflate the lungs) and those that drive the muscles needed for swallowing. By destroying these nerves, this form of polio affects breathing, making it difficult or impossible for the patient to breathe without the support of a ventilator. It can lead to paralysis of the arms and legs and may also affect swallowing and heart functions.<ref name= Hoyt/>
DiagnosisEdit
Paralytic poliomyelitis may be clinically suspected in individuals experiencing acute onset of flaccid paralysis in one or more limbs with decreased or absent tendon reflexes in the affected limbs that cannot be attributed to another apparent cause, and without sensory or cognitive loss.<ref>Template:Cite journal</ref>
A laboratory diagnosis is usually made based on the recovery of poliovirus from a stool sample or a swab of the pharynx. Rarely, it may be possible to identify poliovirus in the blood or in the cerebrospinal fluid. Poliovirus samples are further analysed using reverse transcription polymerase chain reaction (RT-PCR) or genomic sequencing to determine the serotype (i.e., 1, 2, or 3), and whether the virus is a wild or vaccine-derived strain.<ref name = PinkBook2021/>
PreventionEdit
Passive immunizationEdit
In 1950, William Hammon at the University of Pittsburgh purified the gamma globulin component of the blood plasma of polio survivors.<ref name=Hammon_1955>Template:Cite journal</ref> Hammon proposed the gamma globulin, which contained antibodies to poliovirus, could be used to halt poliovirus infection, prevent disease, and reduce the severity of disease in other patients who had contracted polio. The results of a large clinical trial were promising; the gamma globulin was shown to be about 80 percent effective in preventing the development of paralytic poliomyelitis.<ref>Template:Cite journal</ref> It was also shown to reduce the severity of the disease in patients who developed polio.<ref name=Hammon_1955 /> Due to the limited supply of blood plasma gamma globulin was later deemed impractical for widespread use and the medical community focused on the development of a polio vaccine.<ref name=Rinaldo>Template:Cite journal</ref>
VaccineEdit
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Two types of vaccine are used throughout the world to combat polio: an inactivated poliovirus given by injection, and a weakened poliovirus given by mouth. Both types induce immunity to polio and are effective in protecting individuals from disease.<ref name="WHO20162">Template:Cite journal</ref>
The inactivated polio vaccine (IPV) was developed in 1952 by Jonas Salk at the University of Pittsburgh, and announced to the world on 12 April 1955.<ref name="Spice">Template:Cite news</ref> The Salk vaccine is based on poliovirus grown in a type of monkey kidney tissue culture (vero cell line), which is chemically inactivated with formalin.<ref name="Kew_2005" /> After two doses of IPV (given by injection), 90 percent or more of individuals develop protective antibody to all three serotypes of poliovirus, and at least 99 percent are immune to poliovirus following three doses.<ref name="PinkBook2021" />
Subsequently, Albert Sabin developed a polio vaccine that can be administered orally (oral polio vaccine - OPV), comprising a live, attenuated virus. It was produced by the repeated passage of the virus through nonhuman cells at subphysiological temperatures.<ref name="Sabin_1973">Template:Cite journal</ref> The attenuated poliovirus in the Sabin vaccine replicates very efficiently in the gut, the primary site of wild poliovirus infection and replication, but the vaccine strain is unable to replicate efficiently within nervous system tissue.<ref>Template:Cite journal</ref> A single dose of Sabin's trivalent OPV produces immunity to all three poliovirus serotypes in about 50 percent of recipients. Three doses of OPV produce protective antibody to all three poliovirus types in more than 95 percent of recipients.<ref name="PinkBook2021" /> Human trials of Sabin's vaccine began in 1957,<ref name="ScienceOdyssey">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> and in 1958, it was selected, in competition with the live attenuated vaccines of Koprowski and other researchers, by the US National Institutes of Health.<ref name="Sanofi">{{#invoke:citation/CS1|citation |CitationClass=web }} Accessed 16 December 2009.</ref> Licensed in 1962,<ref name="ScienceOdyssey" /> it rapidly became the only oral polio vaccine used worldwide.<ref name="Sanofi" />
OPV efficiently blocks person-to-person transmission of wild poliovirus by oral–oral and fecal–oral routes, thereby protecting both individual vaccine recipients and the wider community. The live attenuated virus may be transmitted from vaccinees to their unvaccinated contacts, resulting in wider community immunity.<ref name="Fine2">Template:Cite journal</ref> IPV confers good immunity but is less effective at preventing spread of wild poliovirus by the fecal–oral route.<ref>Template:Cite journal</ref>
Because the oral polio vaccine is inexpensive, easy to administer, and produces excellent immunity in the intestine (which helps prevent infection with wild virus in areas where it is endemic), it has been the vaccine of choice for controlling poliomyelitis in many countries.<ref name="Peds">Template:Cite journal</ref> On very rare occasions, the attenuated virus in the Sabin OPV can revert into a form that can paralyze.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> In 2017, cases caused by vaccine-derived poliovirus (cVDPV) outnumbered wild poliovirus cases for the first time, due to wild polio cases hitting record lows.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> Most industrialized countries have switched to inactivated polio vaccine, which cannot revert, either as the sole vaccine against poliomyelitis or in combination with oral polio vaccine.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>
An improved oral vaccine (Novel oral polio vaccine type 2 - nOPV2) began development in 2011 and was granted emergency licensing in 2021, and subsequently full licensure in December 2023.<ref name=":2">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> This has greater genetic stability than the traditional oral vaccine and is less likely to revert to a virulent form.<ref name=":2" />
TreatmentEdit
There is no cure for polio, but there are treatments. The focus of modern treatment has been on providing relief of symptoms, speeding recovery and preventing complications. Supportive measures include antibiotics to prevent infections in weakened muscles, analgesics for pain, moderate exercise and a nutritious diet.<ref name=Daniel>Template:Cite book</ref> Treatment of polio often requires long-term rehabilitation, including occupational therapy, physical therapy, braces, corrective shoes and, in some cases, orthopedic surgery.<ref name=Guide />
Portable ventilators may be required to support breathing. Historically, a noninvasive, negative-pressure ventilator, more commonly called an iron lung, was used to artificially maintain respiration during an acute polio infection until a person could breathe independently (generally about one to two weeks). The use of iron lungs is largely obsolete in modern medicine as more modern breathing therapies have been developed<ref>Template:Cite journal</ref> and due to the eradication of polio in most of the world.<ref name="americas_last_2017_11_22_independent_co_uk">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>
Other historical treatments for polio include hydrotherapy, electrotherapy, massage and passive motion exercises, and surgical treatments, such as tendon lengthening and nerve grafting.<ref name=Henry1 />
PrognosisEdit
Patients with abortive polio infections recover completely. In those who develop only aseptic meningitis, the symptoms can be expected to persist for two to ten days, followed by complete recovery.<ref name=Neumann/> In cases of spinal polio, if the affected nerve cells are completely destroyed, paralysis will be permanent; cells that are not destroyed, but lose function temporarily, may recover within four to six weeks after onset.<ref name=Neumann>Template:Cite journal Reproduced online with permission by Post-Polio Health International; retrieved on 10 November 2007.</ref> Half the patients with spinal polio recover fully; one-quarter recover with mild disability, and the remaining quarter are left with severe disability.<ref>Template:Cite book</ref> The degree of both acute paralysis and residual paralysis is likely to be proportional to the degree of viremia, and inversely proportional to the degree of immunity.<ref name= Mueller/> Spinal polio is rarely fatal.<ref name=Silverstein />
Without respiratory support, consequences of poliomyelitis with respiratory involvement include suffocation or pneumonia from aspiration of secretions.<ref name= Goldberg>Template:Cite journal</ref> Overall, 5 to 10 percent of patients with paralytic polio die due to the paralysis of muscles used for breathing. The case fatality rate (CFR) varies by age: 2 to 5 percent of children and up to 15 to 30 percent of adults die.<ref name=PinkBook2021 /> Bulbar polio often causes death if respiratory support is not provided;<ref name= Hoyt /> with support, its CFR ranges from 25 to 75 percent, depending on the age of the patient.<ref name=PinkBook2021 /><ref>Template:Cite journal</ref> When intermittent positive pressure ventilation is available, the fatalities can be reduced to 15 percent.<ref name=Wackers>Template:Cite thesis</ref>
RecoveryEdit
Many cases of poliomyelitis result in only temporary paralysis.<ref name=Henry1 /> Generally in these cases, nerve impulses return to the paralyzed muscle within a month, and recovery is complete in six to eight months.<ref name=Neumann /> The neurophysiological processes involved in recovery following acute paralytic poliomyelitis are quite effective; muscles are able to retain normal strength even if half the original motor neurons have been lost.<ref>Template:Cite journal</ref> Paralysis remaining after one year is likely to be permanent, although some recovery of muscle strength is possible up to 18 months after infection.<ref name=Neumann />
One mechanism involved in recovery is nerve terminal sprouting, in which remaining brainstem and spinal cord motor neurons develop new branches, or axonal sprouts.<ref>Template:Cite journal</ref> These sprouts can reinnervate orphaned muscle fibers that have been denervated by acute polio infection,<ref name=Agre>Template:Cite journal</ref> restoring the fibers' capacity to contract and improving strength.<ref name="Cashman"/> Terminal sprouting may generate a few significantly enlarged motor neurons doing work previously performed by as many as four or five units:<ref name=Gawne_1995 /> a single motor neuron that once controlled 200 muscle cells might control 800 to 1000 cells. Other mechanisms that occur during the rehabilitation phase, and contribute to muscle strength restoration, include myofiber hypertrophy – enlargement of muscle fibers through exercise and activity – and transformation of type II muscle fibers to type I muscle fibers.<ref name=Agre /><ref name = Grimby_1989>Template:Cite journal</ref>
In addition to these physiological processes, the body can compensate for residual paralysis in other ways. Weaker muscles can be used at a higher than usual intensity relative to the muscle's maximal capacity, little-used muscles can be developed, and ligaments can enable stability and mobility.<ref name = Grimby_1989 />
ComplicationsEdit
Residual complications of paralytic polio often occur following the initial recovery process.<ref name= Late /> Muscle paresis and paralysis can sometimes result in skeletal deformities, tightening of the joints, and movement disability. Once the muscles in the limb become flaccid, they may interfere with the function of other muscles. A typical manifestation of this problem is equinus foot (similar to club foot). This deformity develops when the muscles that pull the toes downward are working, but those that pull it upward are not, and the foot naturally tends to drop toward the ground. If the problem is left untreated, the Achilles tendons at the back of the foot retract and the foot cannot take on a normal position. People with polio that develop equinus foot cannot walk properly because they cannot put their heels on the ground. A similar situation can develop if the arms become paralyzed.<ref name= Aftereffects>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>
In some cases the growth of an affected leg is slowed by polio, while the other leg continues to grow normally. The result is that one leg is shorter than the other and the person limps and leans to one side, in turn leading to deformities of the spine (such as scoliosis).<ref name= Aftereffects /> Osteoporosis and increased likelihood of bone fractures may occur. An intervention to prevent or lessen length disparity can be to perform an epiphysiodesis on the distal femoral and proximal tibial/fibular condyles, so that limb's growth is artificially stunted, and by the time of epiphyseal (growth) plate closure, the legs are more equal in length. Alternatively, a person can be fitted with custom-made footwear which corrects the difference in leg lengths. Other surgery to re-balance muscular agonist/antagonist imbalances may also be helpful. Extended use of braces or wheelchairs may cause compression neuropathy, as well as a loss of proper function of the veins in the legs, due to pooling of blood in paralyzed lower limbs.<ref name= Hoyt>Template:Cite book</ref><ref name=MayoComps>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> Complications from prolonged immobility involving the lungs, kidneys and heart include pulmonary edema, aspiration pneumonia, urinary tract infections, kidney stones, paralytic ileus, myocarditis and cor pulmonale.<ref name= Hoyt/><ref name=MayoComps />
Post-polio syndromeEdit
{{#invoke:Labelled list hatnote|labelledList|Main article|Main articles|Main page|Main pages}} Between 25 percent and 50 percent of individuals who have recovered from paralytic polio in childhood can develop additional symptoms decades after recovering from the acute infection,<ref name="NINDS Post-Polio Syndrome Fact Sheet">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> notably new muscle weakness and extreme fatigue. This condition is known as post-polio syndrome (PPS) or post-polio sequelae.<ref name=Cashman>Template:Cite journal</ref> The symptoms of PPS are thought to involve a failure of the oversized motor units created during the recovery phase of the paralytic disease.<ref name=Ramlow_1992>Template:Cite journal</ref><ref name=Annals>Template:Cite journal</ref> Contributing factors that increase the risk of PPS include aging with loss of neuron units, the presence of a permanent residual impairment after recovery from the acute illness, and both overuse and disuse of neurons. PPS is a slow, progressive disease, and there is no specific treatment for it.<ref name=Cashman /> Post-polio syndrome is not an infectious process, and persons experiencing the syndrome do not shed poliovirus.<ref name=PinkBook2021 />
OrthoticsEdit
Paralysis, length differences and deformations of the lower extremities can lead to a hindrance when walking with compensation mechanisms that lead to a severe impairment of the gait pattern. In order to be able to stand and walk safely and to improve the gait pattern, orthotics can be included in the therapy concept. Today, modern materials and functional elements enable the orthosis to be specifically adapted to the requirements resulting from the patient's gait. Mechanical stance phase control knee joints may secure the knee joint in the early stance phases and release again for knee flexion when the swing phase is initiated. With the help of an orthotic treatment with a stance phase control knee joint, a natural gait pattern can be achieved despite mechanical protection against unwanted knee flexion. In these cases, locked knee joints are often used, which have a good safety function, but do not allow knee flexion when walking during swing phase. With such joints, the knee joint remains mechanically blocked during the swing phase. Patients with locked knee joints must swing the leg forward with the knee extended even during the swing phase. This only works if the patient develops compensatory mechanisms, e.g. by raising the body's center of gravity in the swing phase (Duchenne limping) or by swinging the orthotic leg to the side (circumduction).<ref>Template:Cite book</ref><ref>Template:Cite journal</ref><ref>Template:Cite journal</ref>
EpidemiologyEdit
Major polio epidemics were unknown before the 20th century; up until that time, polio was an endemic disease worldwide.<ref name="Trevelyan_2005">Template:Cite journal</ref> Mothers who had survived polio infection passed on temporary immunity to their babies in the womb and through breast milk.<ref name="Baron2">Template:Cite book</ref> As a result, an infant who encountered a polio infection generally suffered only mild symptoms and acquired a long-term immunity to the disease.<ref name=":0">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> With improvements in sanitation and hygiene during the 19th century, the general level of herd immunity in the population declined; this provided circumstances where epidemics of polio became frequent.<ref name=":0" /> It is estimated that epidemic polio killed or paralysed over half a million people every year.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>
Following the widespread use of poliovirus vaccine in the mid-1950s, new cases of poliomyelitis declined dramatically in many industrialized countries.<ref name="Hinman">Template:Cite journal</ref> Efforts to completely eradicate the disease started in 1988 and are ongoing.<ref name=":1" />
Circulating vaccine-derived poliovirusesEdit
The oral polio vaccine, while highly effective, has the disadvantage that it contains a live virus which has been attenuated so that it cannot cause severe illness. The vaccine virus is excreted in the stool, and in under-immunized communities it can spread from person to person. This is known as circulating vaccine-derived poliovirus (cVDPV) or more simply as variant poliovirus.<ref name="www.cdc.gov2022" /><ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>
With prolonged transmission of this kind, the weakened virus can mutate and revert to a form that causes illness and paralysis. Cases of cVDPV now exceed wild-type cases, making it desirable to discontinue the use of the oral polio vaccine as soon as safely possible and instead use other types of polio vaccines.<ref name="www.cdc.gov2022" /><ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>
EradicationEdit
A global effort to eradicate polio – the Global Polio Eradication Initiative – began in 1988, led by the World Health Organization, UNICEF, and The Rotary Foundation.<ref name=":1">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> Polio is one of only two diseases currently the subject of a global eradication program, the other being Guinea worm disease.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> So far, the only diseases completely eradicated by humankind are smallpox, declared eradicated in 1980,<ref name="WHO_smallpox">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref><ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> and rinderpest, declared eradicated in 2011.<ref>Template:Cite press release</ref> In April 2012, the World Health Assembly declared that the failure to completely eradicate polio would be a programmatic emergency for global public health, and that it "must not happen".<ref>Template:Cite book</ref>
These efforts have hugely reduced the number of cases; from an estimated 350,000 cases in 1988 to a low of 483 cases in 2001, after which it remained at a level of about 1,000–2000 cases per year for a number of years.<ref name="eradication">Template:Cite journal</ref><ref name="morbidity">Template:Cite journal</ref>
By 2015, polio was believed to remain naturally spreading in only two countries, Pakistan and Afghanistan,<ref name="eradication1" /><ref name="GlobalPolio2015">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> although it continued to cause outbreaks in other nearby countries due to hidden or re-established transmission.<ref>Wild Poliovirus case list 2000–2010; data in WHO/HQ as of 9 November 2010 {{#invoke:citation/CS1|citation |CitationClass=web }}</ref>
Global surveillance for polio takes two forms. Cases of acute flaccid paralysis (AFP) are tested for the presence and type of poliovirus. In addition, environmental and wastewater samples are tested for the presence of poliovirus - this is an effective method of detecting circulating virus which has not given rise to severe symptoms.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> Here is a summary of both wild polio (WPV) and variant polio (cVDPV) prevalence over the last 5 years:<ref name=":52">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>
- 2019 - 147 cases of WPV1 in Pakistan, and 29 cases in Afghanistan. None were reported elsewhere in the world. cVDPV was detected in 19 countries with 378 confirmed cases.<ref name=":02">Template:Cite journal</ref>
- 2020 - 84 WPV1 cases in Pakistan, 56 in Afghanistan. 32 countries reported cVDPV detection, and there were 1,103 cVDPV cases.<ref name=":02" />
- In 2021, there were just six confirmed cases of wild poliovirus — one in Pakistan, four in Afghanistan, and one in Malawi. The case in Malawi, the country's first in almost three decades and the first in Africa in five years, was seen as a significant setback to the eradication effort.<ref name="GPEI-Malawi2">Template:Cite press release</ref> 23 countries detected cVDPV, with 698 cases.<ref name=":12">Template:Cite journal</ref>
- In 2022, there were 30 confirmed cases of WPV1 reported to WHO, with two cases in Pakistan and 20 Afghanistan respectively, while eight non-endemic cases were recorded in Mozambique, the first cases in the country since 1992. The Mozambique cases derived from the strain of Pakistani origin that caused two confirmed cases in Malawi in 2021.<ref>Template:Cite press release</ref> 24 countries detected cVDPV, with 881 cases.<ref name=":12" />
- In 2023, twelve cases of WPV1 were reported, six each in Afghanistan and Pakistan. 32 countries reported cVDPV, with 524 cases.<ref>Template:Cite journal</ref>
Afghanistan and PakistanEdit
Template:See also The last remaining region with wild polio cases are the South Asian countries Afghanistan and Pakistan.<ref name=":5">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>
During 2011, the CIA ran a fake hepatitis vaccination clinic in Abbottabad, Pakistan, in an attempt to locate Osama bin Laden. This destroyed trust in vaccination programs in the region.<ref>Template:Cite journal</ref><ref>Template:Cite news</ref> There were attacks and deaths among vaccination workers; 66 vaccinators were killed in 2013 and 2014.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref><ref name="thenational.ae" /> In Afghanistan, the Taliban banned house-to-house polio vaccination between 2018 and 2021.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> These factors have set back efforts to eliminate polio by means of vaccination in these countries.<ref>Template:Cite news</ref>
In Afghanistan, 80 cases of polio were reported from 35 districts during 2011. Incidence over the subsequent 10 years has declined to just 4 cases in 2 districts during 2021.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref><ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>
In Pakistan, cases dropped by 97 percent from 2014 to 2018;<ref>Template:Cite news</ref> reasons include 440 million dirham support from the United Arab Emirates to vaccinate more than ten million children,<ref name="thenational.ae">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref><ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> changes in the military situation, and arrests of some of those who attacked polio workers.<ref name=BBC2016>Template:Cite news</ref><ref>Template:Cite news</ref>
AmericasEdit
The Americas were declared polio-free in 1994.<ref name=MMWR_1994>Template:Cite journal</ref> The last known case was a boy in Peru in 1991.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> The US Centers for Disease Control and Prevention recommends polio vaccination boosters for travelers and those who live in countries where the disease is endemic.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>
In July 2022, the US state of New York reported a polio case for the first time in almost a decade in the country; this was attributed to a vaccine-derived strain of the virus.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>
Western PacificEdit
In 2000, polio was declared to have been officially eliminated in 37 Western Pacific countries, including China and Australia.<ref name=Pacific>Template:Cite journal</ref><ref name="D'Souza_2002">Template:Cite journal</ref>
Despite eradication ten years earlier, an outbreak was confirmed in China in September 2011, involving a strain common in Pakistan.<ref>Template:Cite news</ref>
In September 2019, the Department of Health of the Philippines declared a polio outbreak in the country after a single case in a 3-year-old girl.<ref name="Polio in PH">Template:Cite news</ref> In December 2019, acute poliomyelitis was confirmed in an infant in Sabah state, Borneo, Malaysia.<ref name="VOAMalaysia">Template:Cite news</ref> Subsequently, a further three polio cases were reported, with the last case reported in January 2020. Both outbreaks were found to be linked instances of vaccine-derived poliomyelitis.<ref>Template:Cite journal</ref>
EuropeEdit
Europe was declared polio-free in 2002.<ref name=WHO_Europe_2002>Template:Cite press release</ref>
Southeast AsiaEdit
On 27 March 2014, the WHO announced the eradication of poliomyelitis in the South-East Asia Region, which includes eleven countries: Bangladesh, Bhutan, North Korea, India, Indonesia, Maldives, Myanmar, Nepal, Sri Lanka, Thailand and Timor-Leste.<ref name="eradication1">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> With the addition of this region, 80 per cent of the world population was considered to be living in polio-free regions.<ref name="eradication1"/>
Middle EastEdit
In Syria, difficulties in executing immunization programs in the ongoing civil war led to a return of polio, probably in 2012,<ref>Template:Cite news</ref> acknowledged by the WHO in 2013.<ref>Template:Cite news</ref><ref>Template:Cite news</ref> 15 cases were confirmed among children in Syria between October and November 2013 in Deir Ezzor. Later, two more cases, one each in rural Damascus and Aleppo, were identified. It was the first outbreak in Syria since 1999. Doctors and international public health agencies report more than 90 cases of polio in Syria, with fears of contagion in rebel areas from lack of sanitation and safe-water services.<ref name="Suppressed">Template:Cite journal</ref> A vaccination campaign in Syria operated under gunfire and led to the deaths of several vaccinators,<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> but returned vaccination coverage to pre-war levels.<ref>Template:Cite news</ref> Syria is currently free of polio, but is considered "at risk".<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>
In 2024, the Gaza Health Ministry reported that several children have shown symptoms consistent with polio, with laboratory tests confirming that a 10-month-old child is infected with the virus.<ref>Template:Cite news</ref> In 2022, prior to the Israel-Hamas conflict, routine immunization coverage of eligible children exceeded 99%, but fell to less than 90% by the first quarter of 2024, according to the WHO.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> United Nations Secretary-General António Guterres urged for a weeklong cease-fire in Gaza to facilitate vaccinations and prevent a potential polio outbreak, emphasizing the risk faced by many children.<ref>Template:Cite news</ref>
AfricaEdit
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In 2003, in northern Nigeria – a country that at that time was considered provisionally polio free – a fatwa was issued declaring that the polio vaccine was designed to render children sterile.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> Subsequently, polio reappeared in Nigeria and spread from there to several other countries. In 2013, nine health workers administering polio vaccine were targeted and killed by gunmen on motorcycles in Kano, but this was the only attack.<ref>Template:Cite news</ref><ref>Template:Cite news</ref> Local traditional and religious leaders and polio survivors worked to revive the campaign,<ref name="reuters.com">Template:Cite news</ref> and Nigeria was removed from the polio-endemic list in September 2015 after more than a year without any cases,<ref>Template:Cite news</ref> only to be restored to the list in 2016 when two cases were detected.<ref name=Nigeria2016>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>
Africa was declared free of wild polio in August 2020, although cases of circulating vaccine-derived poliovirus type 2 continue to appear in several countries.<ref>Template:Cite journal</ref>
A single case of wild polio that was detected in Malawi in February 2022, and another in Mozambique in May 2022 were both of a strain imported from Pakistan and do not affect the African region's wild poliovirus-free certification status.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref><ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>
HistoryEdit
The effects of polio have been known since prehistory; Egyptian paintings and carvings depict otherwise healthy people with withered limbs, and young children walking with canes.<ref name=Paul_1971>Template:Cite book</ref> The earliest known case of polio is indicated by the remains of a teenage girl discovered in a 4000-year-old burial site in the United Arab Emirates, exhibiting characteristic symptoms of the condition.<ref>Template:Cite book</ref>
The first clinical description was provided by the English physician Michael Underwood in 1789, where he refers to polio as "a debility of the lower extremities".<ref name="Underwood_1789">Template:Cite book</ref> The work of physicians Jakob Heine in 1840 and Karl Oskar Medin in 1890 led to it being known as Heine–Medin disease.<ref name="Pearce_2005">Template:Cite journal</ref> The disease was later called infantile paralysis, based on its propensity to affect children.<ref>Template:Cite book</ref>
Before the 20th century, polio infections were rarely seen in infants before six months of age, most cases occurring in children six months to four years of age. Poorer sanitation of the time resulted in constant exposure to the virus, which enhanced a natural immunity within the population. In developed countries during the late 19th and early 20th centuries, improvements were made in community sanitation, including better sewage disposal and clean water supplies. These changes drastically increased the proportion of children and adults at risk of paralytic polio infection, by reducing childhood exposure and immunity to the disease.<ref name="Robertson_1993">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>
Small localized paralytic polio epidemics began to appear in Europe and the United States around 1900.<ref name = Trevelyan>Template:Cite journal</ref> Outbreaks reached pandemic proportions in Europe, North America, Australia, and New Zealand during the first half of the 20th century. By 1950, the peak age incidence of paralytic poliomyelitis in the United States had shifted from infants to children aged five to nine years, when the risk of paralysis is greater; about one-third of the cases were reported in persons over 15 years of age.<ref name=Melnick_1990>Template:Cite book</ref> Accordingly, the rate of paralysis and death due to polio infection also increased during this time.<ref name = Trevelyan/> In the United States, the 1952 polio epidemic became the worst outbreak in the nation's history. Of the nearly 58,000 cases reported that year, 3,145 died and 21,269 were left with mild to disabling paralysis.<ref name="Zamula">Template:Cite journal</ref> Intensive care medicine has its origin in the fight against polio.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> Most hospitals in the 1950s had limited access to iron lungs for patients unable to breathe without mechanical assistance. Respiratory centers designed to assist the most severe polio patients, first established in 1952 at the Blegdam Hospital of Copenhagen by Danish anesthesiologist Bjørn Ibsen, were the precursors of modern intensive care units (ICU). (A year later, Ibsen would establish the world's first dedicated ICU.)<ref>Template:Cite journal</ref>
The polio epidemics not only altered the lives of those who survived them, but also brought profound cultural changes, spurring grassroots fund-raising campaigns that would revolutionize medical philanthropy, and giving rise to the modern field of rehabilitation therapy. As one of the largest disabled groups in the world, polio survivors also helped to advance the modern disability rights movement through campaigns for the social and civil rights of the disabled. The World Health Organization estimates that there are 10 to 20 million polio survivors worldwide.<ref name=NewsDesk>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> In 1977, there were 254,000 persons living in the United States who had been paralyzed by polio.<ref>Template:Cite journal</ref> According to doctors and local polio support groups, some 40,000 polio survivors with varying degrees of paralysis were living in Germany, 30,000 in Japan, 24,000 in France, 16,000 in Australia, 12,000 in Canada and 12,000 in the United Kingdom in 2001.<ref name= NewsDesk/> Many notable individuals have survived polio and often credit the prolonged immobility and residual paralysis associated with polio as a driving force in their lives and careers.<ref>Template:Cite book</ref>
The disease was very well publicized during the polio epidemics of the 1950s, with extensive media coverage of any scientific advancements that might lead to a cure. Thus, the scientists working on polio became some of the most famous of the century. Fifteen scientists and two laymen who made important contributions to the knowledge and treatment of poliomyelitis are honored by the Polio Hall of Fame, which was dedicated in 1957 at the Roosevelt Warm Springs Institute for Rehabilitation in Warm Springs, Georgia, US. In 2008 four organizations (Rotary International, the World Health Organization, the U.S. Centers for Disease Control and UNICEF) were added to the Hall of Fame.<ref>Template:Cite news</ref><ref>Template:Cite news</ref>
World Polio Day (24 October) as an annual day of awareness was established by Rotary International to commemorate the birth of Jonas Salk, who led the first team to develop a vaccine against poliomyelitis.<ref name=":3">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>
A global effort to eradicate polio – the Global Polio Eradication Initiative (GPEI) – began in 1988, led by the World Health Organization, UNICEF, and The Rotary Foundation.<ref name=":1" /> Since then, international cooperation led by GPEI has reduced polio worldwide by 99 percent, and the campaign is ongoing.<ref name=":3" />
In 2010, wild poliovirus was discovered through importation in 13 different countries. They were Chad, the Democratic Republic of Congo, the Republic of Congo, Kazakhstan, Liberia, Mali, Nepal, Niger, the Russian Federation, Senegal, Tajikistan, Turkmenistan, and Uganda.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>
In 2021, Types 2 and 3 were fully eradicated from every country; however, type 1 cases still remain in Pakistan and Afghanistan.<ref name=":6">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> A majority of countries have successfully eradicated polio, with Pakistan and Afghanistan being the last countries with endemic cases of poliovirus.<ref name=":7">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> The following countries have been considered polio-free, but not confirmed as of April 2024: Somalia, Djibouti, Sudan, Egypt, Libya, Tunisia, Morocco, Palestine, Lebanon, Syria, Jordan, Saudi Arabia, Bahrain, Qatar, Oman, Yemen, the UAE, Iraq, Kuwait, and Iran.<ref name=":7" />
ResearchEdit
Since 2018, Global Polio Eradication Initiative (GPEI) has coordinated efforts both to eliminate polio and to research means of improving surveillance and prevention. At the peak of its work, the programme directly employed 4000 people across 75 countries and managed a budget of nearly U.S. $1 billion.<ref name="Aylward2011">Template:Cite book</ref>
Template:As of, the GPEI had raised 18 billion dollars in funding,<ref name="finance">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> with annual contributions around 800 million to 1 billion dollars. Around 30% of the funding came from the Gates Foundation 30% from developed governments, 27% from countries at risk of polio, and the rest was made up of donations from nonprofits, private funders, and other foundations.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>
The GPEI has identified six directions for continuing research:<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>
- Optimizing oral polio vaccine efficacy
- Developing affordable inactivated polio vaccine
- Managing risks associated with vaccine-derived polioviruses and vaccine-associated paralytic polio (including OPV cessation)
- Antivirals
- Polio diagnostics
- Surveillance research
Even if polio can be eliminated from the world population, vaccination programs should continue for at least ten years.<ref name=":4">Template:Cite journal</ref> The retention of live poliovirus samples in laboratories and vaccine manufacturing facilities (which carry a risk of escape of the virus) should progressively be reduced. To support these two objectives, vaccines are under development which either utilise a virus-like particle, or which derive from a modified virus which cannot reproduce in a human host.<ref name=":4" />
ReferencesEdit
Further readingEdit
- Benison, Saul. “The Enigma of Poliomyelitis: 1910,” in Freedom and Reform: Essays in Honor of Henry Steele Commager, ed. Harold Hyman, (1967).
- Benison, Saul. “The History of Polio Research in the United States: Appraisal and Lessons,” in The Twentieth Century Sciences: Studies in the Biography of Ideas, ed. Gerald Holton, (1972).
- Black, Kathryn. In the shadow of polio : a personal and social history (1996) online
- Hecht, Alan, and I. Edward Alcamo. Polio (2003) online copy, for middle schools
- Template:Cite book
- Template:Cite book, a major scholarly history.
- Rai, Anushree, et al. "Polio returns to the USA: An epidemiological alert." Annals of Medicine and Surgery 82 (2022). online
- Zimmermann, Jonas. "War on Disease: Polio Eradication in the United States." Historia. scriber 15 (2023): 263-280. online
External linksEdit
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