Methylethyltryptamine

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Methylethyltryptamine (MET), also known as N-methyl-N-ethyltryptamine (N,N-MET), is a serotonergic psychedelic of the tryptamine family.<ref name="TiHKAL1997" /><ref name="Shulgin2003" /> It is closely related to dimethyltryptamine (DMT) and to diethyltryptamine (DET).<ref name="SchifanoOrsoliniPapanti2016">Template:Cite book</ref><ref name="HalberstadtGeyer2018">Template:Cite journal</ref> The drug acts as an agonist of the serotonin 5-HT₂ receptors and to a lesser extent as a serotonin releasing agent.<ref name="US11440879B2" /> It was encountered as a novel designer drug in Europe in 2014.<ref name="EMCDDA2015">Template:Cite book</ref>

Use and effects

MET has been briefly mentioned in Alexander Shulgin's TiHKAL (Tryptamines I Have Known and Loved) and other publications, where he has stated it to be orally active as a psychedelic at doses of 80 to 100Template:Nbspmg.<ref name="TiHKAL1997">Template:Cite book</ref><ref name="Shulgin2003">Template:Cite book</ref> The freebase of MET is active as a psychedelic via vaporization at a dose of 15Template:Nbspmg per a 2011 Erowid trip report.<ref name="Erowid2011">"That's okay, you're good" MET trip report - The Vaults of Erowid</ref>

Pharmacology

MET is a serotonin 5-HT_2A and 5-HT_2C receptor partial agonist.<ref name="US11440879B2" /> It shows very weak activity as an agonist of the serotonin 5-HT_1A and 5-HT_2B receptors.<ref name="US11440879B2" /> In addition to acting at the serotonin 5-HT₂ receptors, MET is a serotonin releasing agent with lower potency.<ref name="US11440879B2" /> It produces the head-twitch response, a behavioral proxy of psychedelic effects, in animals.<ref name="HalberstadtGeyer2018" /><ref name="US11440879B2" />

Chemistry

MET, also known as N-methyl-N-ethyltryptamine, is a substituted tryptamine derivative.<ref name="TiHKAL1997" /><ref name="Shulgin2003" /><ref name="US11440879B2">Template:Cite patent</ref> It is closely related to N,N-dimethyltryptamine (DMT) and to other N,N-dialkylated tryptamines.<ref name="TiHKAL1997" /><ref name="Shulgin2003" /><ref name="US11440879B2" />

Analogues of MET besides DMT include DET, DPT, DiPT, DBT, MiPT, MBT, EPT, EiPT, and PiPT, among others.<ref name="TiHKAL1997" /><ref name="Shulgin2003" /> Derivatives of MET include 4-HO-MET, 5-MeO-MET, 5-fluoro-MET, and 7-F-5-MeO-MET.

The lysergamide counterpart of MET is ETH-LAD, an analogue of LSD that was first developed and characterized by Alexander Shulgin.Template:Citation needed

History

MET appears to have first been described in the literature by 1981.<ref name="Smith1981">Template:Cite book</ref> It was specifically mentioned in Michael Valentine Smith's Psychedelic Chemistry.<ref name="Smith1981" /> Subsequently, MET was briefly described in Alexander Shulgin's TiHKAL (Tryptamines I Have Known and Loved) in 1997.<ref name="TiHKAL1997" /> MET was encountered as a novel designer drug in Europe in 2014.<ref name="EMCDDA2015" />

See also

• Bretisilocin (5-fluoro-MET; GM-2505)

External links

• MET - Isomer Design
• MET - Psychonaut Wiki
• MET - Erowid
• The Big & Dandy MET Thread - Bluelight
• MET scraps - Bluelight

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