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Oxycodone/paracetamol, sold under the brand name Percocet among others,<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> is a fixed-dose combination of the opioid oxycodone with paracetamol (acetaminophen), used to treat moderate to severe pain.<ref name="Percocet FDA label" />

In 2022, it was the 98th most commonly prescribed medication in the United States, with more than 6Template:Nbspmillion prescriptions.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref><ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

HistoryEdit

The United States Food and Drug Administration (FDA) first approved oxycodone/paracetamol in 1976, under application ANDA 085106.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

Society and cultureEdit

Implicated in deathsEdit

In June 2009, an FDA advisory panel recommended that Percocet, Vicodin, and every other combination of acetaminophen with narcotic analgesics<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> be limited in their sales because of their contributions to an alleged 400 acetaminophen-related deaths in the U.S. each year, that were attributed to acetaminophen overdose and associated liver damage.<ref>Template:Cite news</ref>

In December 2009, a study found a fivefold increase in oxycodone-related deaths in Ontario, Canada (mostly accidental) between 1991 and 2007; this led to a doubling of all opioid-related deaths in Ontario over the same period.<ref>Template:Cite journal</ref><ref>Template:Cite journal</ref><ref>Template:Cite journal</ref>

ReferencesEdit

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