Protein Z-related protease inhibitor
Protein Z-dependent protease inhibitor (ZPI) is a protein circulating in the blood which inhibits factors Xa and XIa of the coagulation cascade. It is a member of the class of the serine protease inhibitors (serpins). Its name implies that it requires protein Z, another circulating protein, to function properly, but this only applies to its inhibition of factor X.
It is about 72 kDa heavy and 444 amino acids large. It is produced by the liver.
Role in diseaseEdit
Water et al. found deficiency of ZPI in 4.4% of a cohort of patients with thrombophilia (a tendency to thrombosis).<ref name="pmid15461625">Template:Cite journal</ref>
HistoryEdit
Han et al. first described ZPI in 1998.<ref name="pmid9689066">Template:Cite journal</ref> The same group further characterised it in 2000.<ref name="pmid11049983">Template:Cite journal</ref>
ReferencesEdit
External linksEdit
- The MEROPS online database for peptidases and their inhibitors: I04.005 Template:Webarchive