Screened Coulomb potentials implicit solvent model

Template:Short description SCP-ISM, or screened Coulomb potentials implicit solvent model, is a continuum approximation of solvent effects for use in computer simulations of biological macromolecules, such as proteins and nucleic acids, usually within the framework of molecular dynamics.<ref name=":0">Template:Cite journal</ref> It is based on the classic theory of polar liquids, as developed by Peter Debye and corrected by Lars Onsager to incorporate reaction field effects.<ref name=":0" /> The model can be combined with quantum chemical calculations to formally derive a continuum model of solvent effects suitable for computer simulations of small and large molecular systems. The model is included in the CHARMM molecular mechanics code.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

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