Transverse myelitis
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Transverse myelitis (TM) is a rare neurological condition wherein the spinal cord is inflamed. The adjective transverse implies that the spinal inflammation (myelitis) extends horizontally throughout the cross section of the spinal cord;<ref name="West2013" /> the terms partial transverse myelitis and partial myelitis are sometimes used to specify inflammation that affects only part of the width of the spinal cord.<ref name="West2013" /> TM is characterized by weakness and numbness of the limbs, deficits in sensation and motor skills, dysfunctional urethral and anal sphincter activities, and dysfunction of the autonomic nervous system that can lead to episodes of high blood pressure. Signs and symptoms vary according to the affected level of the spinal cord. The underlying cause of TM is unknown. The spinal cord inflammation seen in TM has been associated with various infections, immune system disorders, or damage to nerve fibers, by loss of myelin.<ref name="West2013" /> As opposed to leukomyelitis which affects only the white matter, it affects the entire cross-section of the spinal cord.<ref name="servant99">Template:Cite book</ref> Decreased electrical conductivity in the nervous system can result.Template:Citation needed
Signs and symptomsEdit
Symptoms include weakness and numbness of the limbs, deficits in sensation and motor skills, dysfunctional urethral and anal sphincter activities, and dysfunction of the autonomic nervous system that can lead to episodes of high blood pressure.<ref name="West2013" /> Symptoms typically develop for hours to a few weeks.<ref name="West2013">Template:Cite journal</ref><ref name=":0">Template:Cite journal</ref> Sensory symptoms of TM may include a sensation of pins and needles traveling up from the feet.<ref name="West2013" /> The degree and type of sensory loss will depend upon the extent of the involvement of the various sensory tracts, but there is often a "sensory level" at the spinal ganglion of the segmental spinal nerve, below which sensation of pain or light touch is impaired. Motor weakness occurs due to the involvement of the pyramidal tracts and mainly affects the muscles that flex the legs and extend the arms.<ref name="West2013" />
Disturbances in sensory nerves and motor nerves and dysfunction of the autonomic nervous system at the level of the lesion or below, are noted. Therefore, the signs and symptoms depend on the area of the spine involved.<ref name="Dale2010" /> Back pain can occur at the level of any inflamed segment of the spinal cord.<ref name="West2013" />
If the upper cervical segment of the spinal cord is involved, all four limbs may be affected and there is the risk of respiratory failure – the phrenic nerve which is formed by the cervical spinal nerves C3, C4, and C5 innervates the main muscle of respiration, the diaphragm.<ref>Template:Cite book</ref>
Lesions of the lower cervical region (C5–T1) will cause a combination of upper and lower motor neuron signs in the upper limbs, and exclusively upper motor neuron signs in the lower limbs. Cervical lesions account for about 20% of cases.<ref name="Dale2010" />
A lesion of the thoracic segment (T1–12) will produce upper motor neuron signs in the lower limbs, presenting as a spastic paraparesis. This is the most common location of the lesion, and therefore most individuals will have weakness in the lower limbs.<ref name="Alexander2015">Template:Cite book</ref>
A lesion of the lumbar segment, the lower part of the spinal cord (L1–S5) often produces a combination of upper and lower motor neuron signs in the lower limbs. Lumbar lesions account for about 10% of cases.<ref name="Dale2010" />
CausesEdit
TM is a heterogeneous condition, that is, there are several identified causes. Sometimes the term Transverse myelitis spectrum disorder is used.<ref>Template:Cite journal</ref> In 60% of patients the cause is idiopathic.<ref>Template:Cite news</ref> In rare cases, it may be associated with meningococcal meningitis<ref name="khare90">Template:Cite journal</ref>
When it appears as a comorbid condition with neuromyelitis optica (NMO), it is considered to be caused by NMO-IgG autoimmunity, and when it appears in multiple sclerosis (MS) cases, it's misdiagnosed as multiple sclerosis (MS) or seen as a type of MS. But NMO is a different condition.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>
Other causes of TM include infections, immune system disorders, and demyelinating diseases.<ref name="NIH_2015">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> Viral infections known to be associated with TM include HIV, herpes simplex, herpes zoster, cytomegalovirus, and Epstein-Barr.<ref name="Levin2018">Template:Cite journal</ref> Flavivirus infections such as Zika virus and West Nile virus have also been associated. Viral association of transverse myelitis could result from the infection itself or from the response to it.<ref name="NIH_2015" /> Bacterial causes associated with TM include Mycoplasma pneumoniae, Bartonella henselae, and the types of Borrelia that cause Lyme disease. Lyme disease gives rise to neuroborreliosis which is seen in a small percentage (4 to 5 per cent) of acute transverse myelitis cases.<ref>Template:Cite journal</ref> The diarrhea-causing bacteria Campylobacter jejuni is also a reported cause of transverse myelitis.<ref name="Ross2013">Template:Cite journal</ref>
Other associated causes include the helminth infection schistosomiasis, spinal cord injuries, vascular disorders that impede the blood flow through vessels of the spinal cord, and paraneoplastic syndrome.<ref name="NIH_2015" /> Another exceptionally rare cause is heroin associated transverse myelitis.<ref>Template:Cite journal</ref><ref>Template:Cite journal</ref>
PathophysiologyEdit
This progressive loss of the fatty myelin sheath surrounding the nerves in the affected spinal cord occurs for unclear reasons following infections or due to multiple sclerosis. Infections may cause TM through direct tissue damage or by immune-mediated infection-triggered tissue damage.<ref name=":0" /> The lesions present are usually inflammatory. Spinal cord involvement is usually central, uniform, and symmetric in comparison to multiple sclerosis which typically affects the cord in a patchy way. The lesions in acute TM are mostly limited to the spinal cord with no involvement of other structures in the central nervous system.<ref name=":0" />
Longitudinally extensive transverse myelitisEdit
A proposed special clinical presentation is the "longitudinally extensive transverse myelitis" (LETM), which is defined as a TM with a spinal cord lesion that extends over three or more vertebral segments.<ref>Template:Cite journal</ref> The causes of LETM are also heterogeneous<ref name="pmid26209588">Template:Cite journal</ref> and the presence of MOG auto-antibodies has been proposed as a diagnostic biomarker.<ref name="pmid26209592">Template:Cite journal</ref>
DiagnosisEdit
Diagnostic criteriaEdit
In 2002, the Transverse Myelitis Consortium Working Group proposed the following diagnostic criteria for idiopathic acute transverse myelitis:<ref name="WorkingGroup2002">Template:Cite journal</ref> Template:Columns-list
InvestigationsEdit
Individuals who develop TM are typically transferred to a neurologist who can urgently investigate the patient in a hospital. If breathing is affected, particularly in upper spinal cord lesions, methods of artificial ventilation must be on hand before and during the transfer procedure. The patient should also be catheterized to test for and, if necessary, drain an over-distended bladder. A lumbar puncture can be performed after the MRI or at the time of CT myelography. Corticosteroids are often given in high doses when symptoms begin with the hope that the degree of inflammation and swelling of the spinal cord will be lessened, but whether this is truly effective is still debated.<ref name="gar" />
Differential diagnosisEdit
The differential diagnosis of acute TM includes demyelinating disorders, such as multiple sclerosis and neuromyelitis optica, infections, such as herpes zoster and herpes simplex virus, and other types of inflammatory disorders, such as systemic lupus erythematosus and neurosarcoidosis. It is important to also rule out an acute cause of compression on the spinal cord.<ref>Template:Cite journal</ref>
TreatmentEdit
If treated early, some people experience a complete or near complete recovery. Treatment options also vary according to the underlying cause. One treatment option includes plasmapheresis.<ref>Template:Cite book</ref> Recovery from TM is variable between individuals and also depends on the underlying cause. Some patients begin to recover between weeks 2 and 12 following onset and may continue to improve for up to two years. Other patients may never show signs of recovery.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>
PrognosisEdit
The prognosis for TM depends on whether there is improvement in 3 to 6 months. Complete recovery is unlikely if no improvement occurs within this time. Incomplete recovery can still occur; however, aggressive physical therapy and rehabilitation will be very important. One-third of people with TM experience full recovery, one-third experience fair recovery but have significant neurological deficits, such as spastic gait. The final third experience no recovery at all.<ref name="NIH_2015" />
EpidemiologyEdit
The incidence of TM is 4.6 per 1 million per year, affecting men and women equally. TM can occur at any age, but there are peaks around age 10, age 20, and after age 40.<ref>Template:Cite book</ref>
HistoryEdit
The earliest reports describing the signs and symptoms of transverse myelitis were published in 1882 and 1910 by the English neurologist Henry Bastian.<ref name="Dale2010">Template:Cite book</ref><ref>Template:Cite book</ref>
In 1928, Frank Ford noted that in mumps patients who developed acute myelitis, symptoms only emerged after the mumps infection and associated symptoms began to recede. In an article in The Lancet, Ford suggested that acute myelitis could be a post-infection syndrome in most cases (i.e. a result of the body's immune response attacking and damaging the spinal cord) rather than an infectious disease where a virus or some other infectious agent caused paralysis. His suggestion was consistent with reports in 1922 and 1923 of rare instances in which patients developed "post-vaccinal encephalomyelitis" subsequent to receiving the rabies vaccine which then was made from brain tissue carrying the virus. The pathological examination of those who had died from the disease revealed inflammatory cells and demyelination as opposed to the vascular lesions predicted by Bastian.<ref>Template:Cite news</ref>
Ford's theory of an allergic response being at the root of the disease was later shown to be only partially correct, as some infectious agents such as mycoplasma, measles and rubella<ref>Template:Cite journal</ref> were isolated from the spinal fluid of some infected patients, suggesting that direct infection could contribute to the manifestation of acute myelitis in certain cases.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>
In 1948, Dr. Suchett-Kaye described a patient with rapidly progressing impairment of lower extremity motor function that developed as a complication of pneumonia. In his description, he coined the term transverse myelitis to reflect the band-like thoracic area of altered sensation that patients reported.<ref name="Dale2010" /> The term 'acute transverse myelopathy' has since emerged as an acceptable synonym for 'transverse myelitis', and the two terms are currently used interchangeably in the literature.<ref name="pmid14977560">Template:Cite journal</ref>
The definition of transverse myelitis has also evolved over time. Bastian's initial description included few conclusive diagnostic criteria; by the 1980s, basic diagnostic criteria were established, including acutely developing paraparesis combined with bilateral spinal cord dysfunction for <4 weeks and a well-defined upper sensory level, no evidence of spinal cord compression, and a stable, non-progressive course.<ref>Template:Cite journal</ref><ref>Template:Cite journal</ref> Later definitions, were written to exclude patients with underlying systemic or neurological illnesses and to include only those who progressed to maximum deficit in fewer than 4 weeks.<ref name="pmid2375246">Template:Cite journal</ref>
Society and cultureEdit
In 2016, former Slipknot drummer Joey Jordison revealed that he had been hospitalised by the disease in 2013 and that this was the reason for his controversial firing.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> As the first celebrity to publicly speak about having transverse myelitis, this helped to raise public awareness of the disease. Jordison died in his sleep on July 26, 2021,<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> however it is not known whether the disease had any connection to his death.
EtymologyEdit
The word is from Latin: myelitis transversa and the disorder's name is derived from Greek Template:Transliteration referring to the "spinal cord", and the suffix -itis, which denotes inflammation.<ref name="Chamberlin_2005">Template:Cite book</ref>
See alsoEdit
ReferencesEdit
Further readingEdit
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