Xanthoma
Template:Short description Template:See also Template:Infobox medical condition (new) A xanthoma (pl. xanthomas or xanthomata) (condition: xanthomatosis) is a deposition of yellowish cholesterol-rich material that can appear anywhere in the body in various disease states.<ref name="Andrews">Template:Cite book</ref> They are cutaneous manifestations of lipidosis in which lipids accumulate in large foam cells within the skin.<ref name="Andrews"/> They are associated with hyperlipidemias, both primary and secondary types.Template:Cn
Tendon xanthomas are associated with type II hyperlipidemia, chronic biliary tract obstruction, primary biliary cirrhosis, sitosterolemia and the rare metabolic disease cerebrotendineous xanthomatosis. Palmar xanthomata and tuberoeruptive xanthomata (over knees and elbows) occur in type III hyperlipidemia.Template:Cn
EtymologyEdit
The term xanthoma stems from Greek ξανθός (xanthós) 'yellow', and -ωμα -oma, a suffix forming nouns indicating a mass or tumor.Template:Cn
TypesEdit
XanthelasmaEdit
{{#invoke:Labelled list hatnote|labelledList|Main article|Main articles|Main page|Main pages}}
A xanthelasma is a sharply demarcated yellowish collection of cholesterol underneath the skin, usually on or around the eyelids. Strictly, a xanthelasma is a distinct condition, being called a xanthoma only when becoming larger and nodular, assuming tumorous proportions.<ref>Template:Cite book</ref> Still, it is often classified simply as a subtype of xanthoma.<ref>thefreedictionary.com > xanthelasma Citing: The American Heritage Medical Dictionary Copyright 2007, 2004 and Mosby's Medical Dictionary, 8th edition. 2009</ref>
Xanthoma tuberosumEdit
Xanthoma tuberosum (also known as tuberous xanthoma) is characterized by xanthomas located over tuberosity of the joints.<ref name="Andrews"/>Template:Rp
Xanthoma tendinosumEdit
Xanthoma tendinosum (also tendon xanthoma or tendinous xanthoma<ref name="Bolognia">Template:Cite book</ref>) is clinically characterized by papules and nodules found in the tendons of the hands, feet, and heel.<ref name="Andrews"/>Template:Rp Also associated with familial hypercholesterolemia (FH).<ref name="van_den_Bosch_1998">Template:Cite journal</ref>
Eruptive xanthomaEdit
Eruptive xanthoma (ILDS E78.220) is clinically characterized by small, yellowish-orange to reddish-brown papules surrounded by an erythematous halo that appear suddenly all over the body, especially the hands, buttocks, and the extensor surfaces of the extremities.<ref name="Andrews"/>Template:Rp It tends to be associated with elevated triglycerides.<ref>Template:Cite journal</ref>
Xanthoma planumEdit
Xanthoma planum (ILDS D76.370), also known as plane xanthoma, is clinically characterized by bands or rectangular plates (macules) and plaques in the dermis spread diffusely over large areas of the body.<ref name="Andrews"/>Template:Rp
Palmar xanthomaEdit
Palmar xanthoma is clinically characterized by yellowish plaques that involve the palms and flexural surfaces of the fingers.<ref name="Andrews"/>Template:Rp Palmar xanthomas are characterised by yellowish to orange, flat macules or slightly elevated plaques, often with a central white area which may be localised or generalised. They often arise in the skin folds, especially the palmar creases. They occur in hyperlipoproteinaemia type III and type IIA, and in association with biliary cirrhosis. The presence of palmar xanthomata, like the presence of tendinous xanthomata, is indicative of hypercholesterolaemia.Template:Cn
Tuberoeruptive xanthomaEdit
Tuberoeruptive xanthoma (ILDS E78.210) is clinically characterized by red papules and nodules that appear inflamed and tend to coalesce.<ref name="Andrews"/>Template:Rp Tuberous xanthomata are considered similar, and within the same disease spectrum as eruptive xanthomata.<ref name="Bolognia"/>
Other typesEdit
Other types of xanthoma identified in the Medical Dictionary include:<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>
- Xanthoma diabeticorum: a type of eruptive xanthoma, often with severe diabetes.
- Xanthoma disseminatum: a rare xanthoma consisting of non-X histiocytes on flexural (folded) surfaces, associated with diabetes insipidus.
- Verrucous xanthoma, or histiocytosis Y: a papilloma of the oral mucosa and skin whereby the connective tissue under the epithelium contains histiocytes.
See alsoEdit
ReferencesEdit
External linksEdit
Template:Medical resources Template:Sister project
Template:Diseases of the skin and appendages by morphology Template:Lipidemias