Editing Azapirone (section)

{{Short description|Drug class of psycotropic drugs}}
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[[File:Buspirone.svg|thumb|right|250px|[[Buspirone]], the prototypical azapirone anxiolytic, which contains [[azaspirodecanedione]] and [[pyrimidinylpiperazine]] bound via a [[butyl]] chain.]]

'''Azapirones''' are a class of [[drug]]s used as [[anxiolytic]]s, [[antidepressant]]s, and [[antipsychotic]]s.<ref name="pmid1973936">{{cite journal | author = Eison AS | title = Azapirones: history of development | journal = Journal of Clinical Psychopharmacology | volume = 10 | issue = 3 Suppl | pages = 2S–5S |date=June 1990 | pmid = 1973936 | doi = 10.1097/00004714-199006001-00002| s2cid = 40578767 }}</ref><ref name="pmid8638511">{{cite journal | author = Cadieux RJ | title = Azapirones: an alternative to benzodiazepines for anxiety | journal = American Family Physician | volume = 53 | issue = 7 | pages = 2349–53 |date=May 1996 | pmid = 8638511 }}</ref><ref name="pmid16856115">{{cite journal | vauthors=Chessick CA, Allen MH, Thase M, Batista Miralha da Cunha AB, Kapczinski FF, de Lima MS, dos Santos Souza JJ | title = Azapirones for generalized anxiety disorder | journal = Cochrane Database of Systematic Reviews | volume = 3 | issue = 3| pages = CD006115 | year = 2006 | pmid = 16856115 | editor1-last = Chessick | editor1-first = Cheryl A |  doi = 10.1002/14651858.CD006115| pmc = 8915394 |display-authors=etal}}</ref><ref name="pmid2567039">{{cite journal |vauthors=Feighner JP, Boyer WF | title = Serotonin-1A anxiolytics: an overview | journal = Psychopathology | volume = 22 Suppl 1 | issue = 1| pages = 21–6 | year = 1989 | pmid = 2567039 | doi = 10.1159/000284623}}</ref> They are commonly used as [[Augmentation (psychiatry)|add-on]]s to other [[antidepressant]]s, such as [[selective serotonin reuptake inhibitor]]s (SSRIs).<ref>{{Cite book|chapter = Pharmacological treatment of social anxiety disorder|doi = 10.1159/000351960|pmid = 25225024 |volume=29 |year=2013 |pages=144–53 |vauthors=Masdrakis VG, Turic D, Baldwin DS|isbn = 978-3-318-02463-0|title = Anxiety Disorders|series = Modern Trends in Pharmacopsychiatry}}</ref><ref name="pmid8827420">{{cite journal |vauthors=Van Ameringen M, Mancini C, Wilson C | title = Buspirone augmentation of selective serotonin reuptake inhibitors (SSRIs) in social phobia | journal = Journal of Affective Disorders | volume = 39 | issue = 2 | pages = 115–21 |date=July 1996 | pmid = 8827420 | doi = 10.1016/0165-0327(96)00030-4}}</ref><ref name="pmid9180827">{{cite journal |vauthors=Bouwer C, Stein DJ | title = Buspirone is an effective augmenting agent of serotonin selective re-uptake inhibitors in severe treatment-refractory depression | journal = South African Medical Journal | volume = 87 | issue = 4 Suppl | pages = 534–7, 540 |date=April 1997 | pmid = 9180827 }}</ref><ref name="pmid9864079">{{cite journal |vauthors=Dimitriou EC, Dimitriou CE | title = Buspirone augmentation of antidepressant therapy | journal = Journal of Clinical Psychopharmacology | volume = 18 | issue = 6 | pages = 465–9 |date=December 1998 | pmid = 9864079 | doi = 10.1097/00004714-199812000-00009}}</ref><ref name="pmid11465522">{{cite journal |vauthors=Appelberg BG, Syvälahti EK, Koskinen TE, Mehtonen OP, Muhonen TT, Naukkarinen HH | title = Patients with severe depression may benefit from buspirone augmentation of selective serotonin reuptake inhibitors: results from a placebo-controlled, randomized, double-blind, placebo wash-in study | journal = The Journal of Clinical Psychiatry | volume = 62 | issue = 6 | pages = 448–52 |date=June 2001 | pmid = 11465522 | doi = 10.4088/JCP.v62n0608}}</ref><ref name="pmid12667165">{{cite journal |vauthors=Yamada K, Yagi G, Kanba S | title = Clinical efficacy of tandospirone augmentation in patients with major depressive disorder: a randomized controlled trial | journal = Psychiatry and Clinical Neurosciences | volume = 57 | issue = 2 | pages = 183–7 |date=April 2003 | pmid = 12667165 | doi = 10.1046/j.1440-1819.2003.01099.x| doi-access = free }}</ref>