Editing CADASIL (section)

{{Infobox medical condition (new)
| name            = CADASIL
| image           = CADASIL.jpg
| caption         = Brain [[Magnetic resonance imaging|MRI]] from patients with CADASIL showing multiple lesions.
| synonyms        = CADASIL syndrome
| symptoms        =Migraine headaches
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'''CADASIL''' or '''CADASIL syndrome''', involving '''cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy''', is the most common form of hereditary [[stroke]] disorder and is thought to be caused by [[mutation]]s of the ''[[NOTCH3]]'' gene on [[chromosome 19]].<ref>{{cite journal |vauthors=Joutel A, Corpechot C, Ducros A |title=Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia |journal=Nature |volume=383 |issue=6602 |pages=707–10 |date=October 1996 |pmid=8878478 |doi=10.1038/383707a0 |display-authors=etal|bibcode=1996Natur.383..707J |s2cid=4351873 }}</ref> The disease belongs to a family of disorders called the [[leukodystrophies]]. The most common clinical manifestations are [[migraine]] headaches and [[transient ischemic attack]]s or strokes, which usually occur between 40 and 50 years of age, although [[Magnetic resonance imaging|MRI]] is able to detect signs of the disease years prior to clinical manifestation of disease.<ref name="Chabriat1995">{{cite journal |vauthors=Chabriat H, Vahedi K, Iba-Zizen MT |title=Clinical spectrum of CADASIL: a study of 7 families. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy |journal=Lancet |volume=346 |issue=8980 |pages=934–9 |date=October 1995 |pmid=7564728 |display-authors=etal| doi = 10.1016/s0140-6736(95)91557-5 |s2cid=44289660 }}</ref><ref>{{cite book |author1=James, William D. |author2=Berger, Timothy G. |title=Andrews' Diseases of the Skin: clinical Dermatology |url=https://archive.org/details/andrewsdiseasess00mdwi_659 |url-access=limited |publisher=Saunders Elsevier |year=2006 |page=[https://archive.org/details/andrewsdiseasess00mdwi_659/page/n555 545] |isbn=978-0-7216-2921-6 |display-authors=etal}}</ref>

The condition was identified and named by French researchers [[Marie-Germaine Bousser]] and [[Elisabeth Tournier-Lasserve]] in the 1990s.<ref>{{Cite web|url=https://www.cadasilfoundation.org/bousser.html|title=CADASIL History|website=www.cadasilfoundation.org|access-date=2018-03-03|archive-date=2021-05-15|archive-url=https://web.archive.org/web/20210515112410/https://www.cadasilfoundation.org/bousser.html|url-status=dead}}</ref><ref>{{cite journal|pmid=9026542|title=[CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy)] - Abstract|journal=Journal des Maladies Vasculaires|volume=21|issue=5|pages=277–82|year=1996|last1=Chabriat|first1=H.|last2=Joutel|first2=A.|last3=Vahedi|first3=K.|last4=Iba-Zizen|first4=M. T.|last5=Tournier-Lasserve|first5=E.|last6=Bousser|first6=M. G.}}</ref> Together with two other researchers, [[Hugues Chabriat]] and [[Anne Joutel]], they received the 2019 [[The Brain Prize|Brain Prize]] for their research into the condition.<ref>{{Cite web|last=Office|first=FENS|title=The Brain Prize 2019: French neuroscientists honoured for outstanding research into small vessel strokes in the brain|url=https://www.fens.org/News-Activities/News/20191/031/The-Brain-Prize-2019-awarded/|access-date=2021-03-04|website=FENS.org|language=English|archive-date=2021-05-15|archive-url=https://web.archive.org/web/20210515112411/https://www.fens.org/News-Activities/News/20191/031/The-Brain-Prize-2019-awarded/|url-status=dead}}</ref>