Editing CD36 (section)

{{cs1 config|name-list-style=vanc}}
{{Short description|Mammalian protein found in humans}}
{{Infobox_gene}}

'''CD36''' ([[cluster of differentiation]] 36), also known as '''platelet glycoprotein 4''', '''fatty acid translocase''' ('''FAT'''), scavenger receptor class B member 3 ('''SCARB3'''), and glycoproteins 88 ('''GP88'''), IIIb ('''GPIIIB'''), or IV ('''GPIV''') is a [[protein]] that in humans is encoded by the ''CD36'' [[gene]]. The CD36 antigen is an [[integral membrane protein]] found on the surface of many cell types in vertebrate animals. It imports fatty acids inside cells and is a member of the class B [[scavenger receptor (immunology)|scavenger receptor]] family of [[cell (biology)|cell]] surface proteins. CD36 binds many [[protein ligands|ligands]] including [[collagen]],<ref name="pmid2468670">{{cite journal | vauthors = Tandon NN, Kralisz U, Jamieson GA | title = Identification of glycoprotein IV (CD36) as a primary receptor for platelet-collagen adhesion | journal = The Journal of Biological Chemistry | volume = 264 | issue = 13 | pages = 7576–83 | date = May 1989 | doi = 10.1016/S0021-9258(18)83273-2 | pmid = 2468670 | doi-access = free }}</ref> [[thrombospondin]],<ref name="pmid1379600">{{cite journal | vauthors = Silverstein RL, Baird M, Lo SK, Yesner LM | title = Sense and antisense cDNA transfection of CD36 (glycoprotein IV) in melanoma cells. Role of CD36 as a thrombospondin receptor | journal = The Journal of Biological Chemistry | volume = 267 | issue = 23 | pages = 16607–12 | date = August 1992 | doi = 10.1016/S0021-9258(18)42046-7 | pmid = 1379600 | doi-access = free }}</ref> [[erythrocyte]]s parasitized with ''[[Plasmodium falciparum]]'',<ref name="pmid2473841">{{cite journal | vauthors = Oquendo P, Hundt E, Lawler J, Seed B | title = CD36 directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes | journal = Cell | volume = 58 | issue = 1 | pages = 95–101 | date = July 1989 | pmid = 2473841 | doi = 10.1016/0092-8674(89)90406-6 | s2cid = 22059108 }}</ref> oxidized [[low density lipoprotein]],<ref name="pmid7685021">{{cite journal | vauthors = Endemann G, Stanton LW, Madden KS, Bryant CM, White RT, Protter AA | title = CD36 is a receptor for oxidized low density lipoprotein | journal = The Journal of Biological Chemistry | volume = 268 | issue = 16 | pages = 11811–6 | date = June 1993 | doi = 10.1016/S0021-9258(19)50272-1 | pmid = 7685021 | doi-access = free }}</ref><ref name="pmid7538425">{{cite journal | vauthors = Nicholson AC, Frieda S, Pearce A, Silverstein RL | title = Oxidized LDL binds to CD36 on human monocyte-derived macrophages and transfected cell lines. Evidence implicating the lipid moiety of the lipoprotein as the binding site | journal = Arteriosclerosis, Thrombosis, and Vascular Biology | volume = 15 | issue = 2 | pages = 269–75 | date = February 1995 | pmid = 7538425 | doi = 10.1161/01.ATV.15.2.269 | doi-access = free }}</ref> native [[lipoproteins]],<ref name="pmid9555943">{{cite journal | vauthors = Calvo D, Gómez-Coronado D, Suárez Y, Lasunción MA, Vega MA | title = Human CD36 is a high affinity receptor for the native lipoproteins HDL, LDL, and VLDL | journal = Journal of Lipid Research | volume = 39 | issue = 4 | pages = 777–88 | date = April 1998 | doi = 10.1016/S0022-2275(20)32566-9 | pmid = 9555943 | url = http://www.jlr.org/cgi/pmidlookup?view=long&pmid=9555943 | archive-url = https://archive.today/20130415062705/http://www.jlr.org/cgi/pmidlookup?view=long&pmid=9555943 | url-status = dead | archive-date = April 15, 2013 | doi-access = free }}</ref> oxidized [[phospholipids]],<ref name="pmid12105195">{{cite journal | vauthors = Podrez EA, Poliakov E, Shen Z, Zhang R, Deng Y, Sun M, Finton PJ, Shan L, Gugiu B, Fox PL, Hoff HF, Salomon RG, Hazen SL | display-authors = 6 | title = Identification of a novel family of oxidized phospholipids that serve as ligands for the macrophage scavenger receptor CD36 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 41 | pages = 38503–16 | date = October 2002 | pmid = 12105195 | doi = 10.1074/jbc.M203318200 | doi-access = free }}</ref> and long-chain [[fatty acid]]s.<ref name="pmid8694909">{{cite journal | vauthors = Baillie AG, Coburn CT, Abumrad NA |author3-link=Nada Abumrad | title = Reversible binding of long-chain fatty acids to purified FAT, the adipose CD36 homolog | journal = The Journal of Membrane Biology | volume = 153 | issue = 1 | pages = 75–81 | date = September 1996 | pmid = 8694909 | doi = 10.1007/s002329900111 | s2cid = 5911289 }}</ref>

Work in genetically modified rodents suggest a role for CD36 in [[fatty acid]] metabolism,<ref name="pmid12021254">{{cite journal | vauthors = Hajri T, Han XX, Bonen A, Abumrad NA | title = Defective fatty acid uptake modulates insulin responsiveness and metabolic responses to diet in CD36-null mice | journal = The Journal of Clinical Investigation | volume = 109 | issue = 10 | pages = 1381–9 | date = May 2002 | pmid = 12021254 | pmc = 150975 | doi = 10.1172/JCI14596 }}</ref><ref name="pmid14640889">{{cite journal | vauthors = Pravenec M, Landa V, Zídek V, Musilová A, Kazdová L, Qi N, Wang J, St Lezin E, Kurtz TW | display-authors = 6 | title = Transgenic expression of CD36 in the spontaneously hypertensive rat is associated with amelioration of metabolic disturbances but has no effect on hypertension | journal = Physiological Research | volume = 52 | issue = 6 | pages = 681–8 | year = 2003 | doi = 10.33549/physiolres.930380 | pmid = 14640889 | url = http://www.biomed.cas.cz/physiolres/pdf/52/52_681.pdf }}</ref><ref name="pmid34880245">{{cite journal | vauthors = Mistry JJ, Bowles KM, Rushworth SA | title = Free fatty-acid transport via CD36 drives β-oxidation-mediated hematopoietic stem cell response to infection | journal = Nature Communications | volume = 12 | issue = 1 | date = December 2021 | page = 7130 | pmid = 34880245 | doi = 10.1038/s41467-021-27460-9 | pmc = 8655073 | bibcode = 2021NatCo..12.7130M }}</ref> [[heart disease]],<ref name="pmid10772649">{{cite journal | vauthors = Febbraio M, Podrez EA, Smith JD, Hajjar DP, Hazen SL, Hoff HF, Sharma K, Silverstein RL | display-authors = 6 | title = Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice | journal = The Journal of Clinical Investigation | volume = 105 | issue = 8 | pages = 1049–56 | date = April 2000 | pmid = 10772649 | pmc = 300837 | doi = 10.1172/JCI9259 }}</ref> taste,<ref name="pmid16276419">{{cite journal | vauthors = Laugerette F, Passilly-Degrace P, Patris B, Niot I, Febbraio M, Montmayeur JP, Besnard P | title = CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions | journal = The Journal of Clinical Investigation | volume = 115 | issue = 11 | pages = 3177–84 | date = November 2005 | pmid = 16276419 | pmc = 1265871 | doi = 10.1172/JCI25299 }}</ref><ref name="Pepino_2012">{{cite journal | vauthors = Pepino MY, Love-Gregory L, Klein S, Abumrad NA | title = The fatty acid translocase gene CD36 and lingual lipase influence oral sensitivity to fat in obese subjects | journal = Journal of Lipid Research | volume = 53 | issue = 3 | pages = 561–6 | date = March 2012 | pmid = 22210925 | pmc = 3276480 | doi = 10.1194/jlr.M021873  |doi-access=free }}</ref><ref name="pmid24631296">{{cite journal | vauthors = DiPatrizio NV | title = Is fat taste ready for primetime? | journal = Physiology & Behavior | volume = 136 | pages = 145–54 | date = September 2014 | pmid = 24631296 | pmc = 4162865 | doi = 10.1016/j.physbeh.2014.03.002 }}</ref> and dietary fat processing in the [[intestine]].<ref name="pmid15841205">{{cite journal | vauthors = Drover VA, Ajmal M, Nassir F, Davidson NO, Nauli AM, Sahoo D, Tso P, Abumrad NA | display-authors = 6 | title = CD36 deficiency impairs intestinal lipid secretion and clearance of chylomicrons from the blood | journal = The Journal of Clinical Investigation | volume = 115 | issue = 5 | pages = 1290–7 | date = May 2005 | pmid = 15841205 | pmc = 1074677 | doi = 10.1172/JCI21514 }}</ref> It may be involved in [[glucose intolerance]], [[atherosclerosis]], arterial [[hypertension]], [[diabetes]], [[cardiomyopathy]], [[Alzheimer's disease]] and various [[cancers]], mostly of [[epithelium|epithelial origin]] ([[breast cancer|breast]], [[prostate cancer|prostate]], [[ovary cancer|ovary]], and [[colon cancer|colon]]) and also for [[hepatic carcinoma]] and [[gliomas]].<ref name="pmid17673938">{{cite journal | vauthors = Rać ME, Safranow K, Poncyljusz W | title = Molecular basis of human CD36 gene mutations | journal = Molecular Medicine | volume = 13 | issue = 5–6 | pages = 288–96 | year = 2007 | pmid = 17673938 | pmc = 1936231 | doi = 10.2119/2006-00088.Rac }}</ref><ref name="pmid30069479">{{cite journal | author1 = Ana-Maria Enciu | author2 = Eugen Radu | author3 = Ionela Daniela Popescu | author4 = Mihail Eugen Hinescu | author5 = Laura Cristina Ceafalan | title = Targeting CD36 as Biomarker for Metastasis Prognostic: How Far from Translation into Clinical Practice? | journal = BioMed Research International | volume = 2018 | year = 2018 | pages = 1–12 | pmid = 30069479 | pmc = 6057354 | doi = 10.1155/2018/7801202 | doi-access = free }}</ref><ref name="pmid31410189">{{cite journal | author1 = Jingchun Wang | author2 = Yongsheng Li | title = CD36 tango in cancer: signaling pathways and functions | journal = Theranostics | volume = 9 | issue = 17 | pages = 4893–490 | year = 2019 | pmid = 31410189 | pmc = 6691380 | doi = 10.7150/thno.36037 }}</ref>