Editing DeCODE genetics (section)

{{short description|Icelandic biopharmaceutical company}}
{{Redirect-distinguish-text|deCODEme|[[DecodeME]], a genetic study into risk factors for ME/CFS}}
{{Promotional|date=July 2024}}
{{Use dmy dates|date=March 2020}}
{{Infobox company
| name = deCODE genetics, Inc.
| logo = DeCODE-genetics-logo-transparent-web.png
| type = Private
| slogan =
| foundation = 1996
| location = [[Reykjavík]], [[Iceland]]
| key_people = [[Kári Stefánsson]], CEO
| num_employees = 201-500
| industry = [[Genetics]]
| products =
| revenue = USD 106.5 Million (2020)
| parent = [[Amgen]] (2012 - present)
| homepage = [http://www.decode.com/ www.decode.com]
}}
{{lowercase title|title=deCODE Genetics}}
'''deCODE genetics''' ({{langx|is|Íslensk erfðagreining}}) is a [[biopharmaceutical]] company based in [[Reykjavík]], [[Iceland]]. The company was founded in 1996 by [[Kári Stefánsson]]<ref>Announcement of deCODE launching operations, and an interview with Stefánsson on the company's goals, in the country's principal newspaper ''[http://timarit.is/view_page_init.jsp?issId=128501&pageId=1854989&lang=is&q=deCODE%20genetics Morgunblaðið]'', 31 May 1996. Co-founders were pediatrician Kristleifur Kristjánsson, who worked at the company for twenty years, and psychiatrist and poet [[Ernir Kristján Snorrason]].</ref> with the aim of using population genetics studies to identify variations in the human genome associated with common diseases, and to apply these discoveries "to develop novel methods to identify, treat and prevent diseases."<ref>Good early summary of approach and mission is in the [https://www.decode.com/icelandic-genomics-company-identifies-location-of-gene-for-essential-tremor/ company's first press release], announcing the isolation of a disease gene, 25 August 1997</ref>

As of 2019, more than two-thirds of the adult population of Iceland was participating in the company's research efforts,<ref>Anna Azvolinsky, "Master Decoder: A Profile of Kári Stefánsson," [https://www.the-scientist.com/profile/master-decoder--a-profile-of-kri-stefnsson-65517 ''The Scientist''], 1 March 2019</ref> and this "population approach" serves as a model for large-scale precision medicine and national genome projects around the world.<ref name=mjd>{{Cite journal |last=Daly |first=Mark J. |date=March 2018 |title=2017 William Allan Award Introduction: Kári Stefansson |url=https://linkinghub.elsevier.com/retrieve/pii/S0002929718300107 |journal=The American Journal of Human Genetics |language=en |volume=102 |issue=3 |pages=350 |doi=10.1016/j.ajhg.2018.01.010 |pmc=5985355 |pmid=29499158}}</ref> deCODE is probably best known for its discoveries in human genetics, published in major scientific journals and widely reported in the international media. But it has also made pioneering contributions to the realization of [[precision medicine]] more broadly, through public engagement in large-scale scientific research; the development of DNA-based disease risk testing for individuals and across health systems; and new models of private sector participation and partnership in basic science and public health.<ref>deCODE's [https://www.decode.com/publications/ principal publications] and its [https://www.decode.com/news-events/ news releases] since its founding are available on its [https://www.decode.com/ website].</ref>

Since 2012, it has been an independent subsidiary of [[Amgen]] and its capabilities and discoveries have been used directly in the discovery and development of novel drugs. This example has helped to spur investment in genomics and precision therapeutics by other pharmaceutical and biotechnology companies.<ref>Major investments in population genomics by pharmaceutical companies since 2012 include those by [https://investor.regeneron.com/news-releases/news-release-details/regeneron-and-geisinger-health-system-announce-major-human Regeneron], [https://www.nature.com/news/astrazeneca-launches-project-to-sequence-2-million-genomes-1.19797 AstraZeneca], [https://genomicsmed.ie/abbvie-gmi-announce-landmark-population-genomics-alliance/ AbbVie] {{Webarchive|url=https://web.archive.org/web/20190801215731/http://genomicsmed.ie/abbvie-gmi-announce-landmark-population-genomics-alliance/ |date=1 August 2019 }}, [https://www.helsinki.fi/en/news/health-news/gsk-and-sanofi-join-finngen-a-large-scale-genome-study-of-the-finnish-population Glaxo], and others.</ref>