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{{lowercase}} '''E-Science''' or '''eScience''' is computationally intensive [[science]] that is carried out in highly distributed [[computer network|network]] environments, or science that uses immense [[data]] sets that require [[grid computing]]; the term sometimes includes technologies that enable distributed collaboration, such as the [[Access Grid]]. The term was created by John Taylor, the Director General of the United Kingdom's [[Office of Science and Technology]] in 1999 and was used to describe a large funding initiative starting in November 2000. E-science has been more broadly interpreted since then, as "the application of computer technology to the undertaking of modern scientific investigation, including the preparation, experimentation, data collection, results dissemination, and long-term storage and accessibility of all materials generated through the scientific process. These may include data modeling and analysis, electronic/digitized laboratory notebooks, raw and fitted data sets, manuscript production and draft versions, pre-prints, and print and/or electronic publications."<ref name=":0">Bohle, S. "What is E-science and How Should it Be Managed?" Nature.com, Spektrum der Wissenschaft (Scientific American), http://www.scilogs.com/scientific_and_medical_libraries/what-is-e-science-and-how-should-it-be-managed/.</ref> In 2014, [https://escience-conference.org/ IEEE eScience Conference Series] condensed the definition to "eScience promotes innovation in collaborative, computationally- or data-intensive research across all disciplines, throughout the research lifecycle" in one of the working definitions used by the organizers.<ref>IEEE International Conference on eScience, homepage, accessed December 18, 2014, https://escience-conference.org/</ref> E-science encompasses "what is often referred to as [[big data]] [which] has revolutionized science... [such as] the Large Hadron Collider (LHC) at CERN... [that] generates around 780 terabytes per year... highly data intensive modern fields of science...that generate large amounts of E-science data include: [[computational biology]], [[bioinformatics]], genomics"<ref name=":0" /> and the human [[digital footprint]] for the [[social sciences]].<ref name="Hilbert_DT&SC7.2">DT&SC 7-2: Computational Social Science. https://www.youtube.com/watch?v=TEo0Au1brHs From the DT&SC online course at the University of California: https://canvas.instructure.com/courses/949415</ref> [[Turing Award]] winner [[Jim Gray (computer scientist)|Jim Gray]] imagined "data-intensive science" or "[[e-science]]" as a "fourth paradigm" of science ([[Empirical research|empirical]], [[Basic research|theoretical]], computational and now data-driven) and asserted that "everything about science is changing because of the impact of information technology" and the [[information explosion|data deluge]].<ref name="TansleyTolle2009">{{cite book|author1=Stewart Tansley|author2=Kristin Michele Tolle|title=The Fourth Paradigm: Data-intensive Scientific Discovery|url=https://books.google.com/books?id=oGs_AQAAIAAJ|year=2009|publisher=Microsoft Research|isbn=978-0-9825442-0-4}}</ref><ref name="BellHey2009">{{cite journal|last1=Bell|first1=G.|last2=Hey|first2=T.|last3=Szalay|first3=A.|title=COMPUTER SCIENCE: Beyond the Data Deluge|journal=Science|volume=323|issue=5919|year=2009|pages=1297β1298|issn=0036-8075|doi=10.1126/science.1170411|pmid=19265007|s2cid=9743327 }}</ref> E-Science revolutionizes both fundamental legs of the [[scientific method]]: [[empirical research]], especially through digital [[big data]]; and [[scientific theory]], especially through [[computer simulation]] model building.<ref>DT&SC 7-1: Introduction to e-Science: https://www.youtube.com/watch?v=9x3d75ZMuYU . From the DT&SC online course at the University of California: https://canvas.instructure.com/courses/949415</ref><ref name="HilbertICT4ICT4D">Hilbert, M. (2015). e-Science for Digital Development: ICT4ICT4D. Centre for Development Informatics, SEED, University of Manchester. {{cite web |url=http://www.seed.manchester.ac.uk/medialibrary/IDPM/working_papers/di/di-wp60.pdf |title=Archived copy |access-date=2015-08-13 |url-status=dead |archive-url=https://web.archive.org/web/20150924100018/http://www.seed.manchester.ac.uk/medialibrary/IDPM/working_papers/di/di-wp60.pdf |archive-date=2015-09-24 }}</ref> These ideas were reflected by The White House's Office and Science Technology Policy in February 2013, which slated many of the aforementioned e-Science output products for preservation and access requirements under the memorandum's directive.<ref>Executive Office of the President, Office of Science and Technology Policy, "Memorandum for the Heads of Executive Departments and Agencies: Increasing Access to the Results of Federally Funded Scientific Research." February 22, 2013, accessed July 7, 2013, https://obamawhitehouse.archives.gov/sites/default/files/microsites/ostp/ostp_public_access_memo_2013.pdf.</ref> E-sciences include particle physics, earth sciences and [[social simulation]]s.
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