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Enantioselective synthesis
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{{Short description|Chemical reaction(s) which favor one chiral isomer over another}} {{Use dmy dates|date=April 2022}} [[File:Sharpless Dihydroxylation Scheme.png|thumb|500px|In the [[Sharpless dihydroxylation]] reaction the chirality of the product can be controlled by the "[[AD-mix]]" used. This is an example of enantioselective synthesis using [[asymmetric induction]]<br /><br />Key: R<sub>L</sub> = Largest substituent; R<sub>M</sub> = Medium-sized substituent; R<sub>S</sub> = Smallest substituent]] [[File:Chirality with hands.svg|300px|thumb|Two enantiomers of a generic [[alpha amino acid]] {{legend|black|[[Carbon]] at the [[chiral center]]}} {{legend|#ff4500|[[Carboxylic acid]] group}} {{legend|#00dfff|R group}} {{legend|grey|[[Hydrogen]]}}]] '''Enantioselective synthesis''', also called '''asymmetric synthesis''',<ref>{{GoldBookRef|title=asymmetric synthesis| file = A00484}}</ref> is a form of [[chemical synthesis]]. It is defined by [[IUPAC]] as "a [[chemical reaction]] (or reaction sequence) in which one or more new elements of [[Chirality (chemistry)|chirality]] are formed in a substrate molecule and which produces the [[stereoisomer]]ic ([[enantiomer]]ic or [[diastereomer]]ic) products in [[Enantiomeric excess|unequal amounts]]."<ref>{{GoldBookRef|title=stereoselective synthesis|file = S05990}}</ref> Put more simply: it is the synthesis of a compound by a method that favors the formation of a specific enantiomer or diastereomer. Enantiomers are stereoisomers that have opposite configurations at every chiral center. Diastereomers are stereoisomers that differ at one or more chiral centers. Enantioselective synthesis is a key process in modern chemistry and is particularly important in the field of [[pharmaceuticals]], as the different [[enantiomer]]s or [[diastereomer]]s of a molecule often have different [[biological activity]].
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