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Entorhinal cortex
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{{short description|Area of the temporal lobe of the brain}}{{Infobox brain | Name = Entorhinal cortex | Pronunciation = ɛntəɹ'ɪnəl | Latin = cortex entorhinalis | Image = Gray-Brodman-Entorhinal Cortex EC .png | Caption = Medial surface. (Entorhinal cortex approximately maps to areas 28 and 34, at lower left.) | Image2 = Medial surface of cerebral cortex - entorhinal cortex.png | Caption2 = Medial surface of right hemisphere. Entorhinal cortex visible at near bottom. | Width = 300 | IsPartOf = [[Temporal lobe]] | Components = | Artery = [[Posterior cerebral artery|Posterior cerebral]]<br/>[[Choroid artery|Choroid]] | Vein = [[Inferior striate vein|Inferior striate]] }} The '''entorhinal cortex''' ('''EC''') is an area of the brain's [[allocortex]], located in the [[medial temporal lobe]], whose functions include being a widespread network hub for [[memory]], navigation, and the perception of time.<ref name=":0">Integrating time from experience in the lateral entorhinal cortex Albert Tsao, Jørgen Sugar, Li Lu, Cheng Wang, James J. Knierim, May-Britt Moser & Edvard I. Moser Naturevolume 561, pages57–62 (2018)</ref> The EC is the main interface between the [[hippocampus]] and [[neocortex]]. The [[EC-hippocampus system]] plays an important role in declarative (autobiographical/episodic/semantic) memories and in particular [[spatial memory|spatial memories]] including [[memory formation]], [[memory consolidation]], and memory optimization in [[sleep]]. The EC is also responsible for the pre-processing (familiarity) of the input signals in the reflex [[nictitating membrane]] response of classical trace conditioning; the association of impulses from the [[Human eye|eye]] and the [[ear]] occurs in the entorhinal cortex.
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