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Essential thrombocythemia
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{{short description|Overproduction of platelets in the bone marrow}} {{Infobox medical condition (new) | name = Essential thrombocythemia | synonyms = Essential thrombocythaemia, essential thrombocytosis, primary thrombocytosis | image = Essential thrombocythemia (2).jpg | caption = [[Histopathology|Histopathological]] image representing a [[Bone marrow examination|bone marrow aspirate]] in a patient with essential thrombocythemia. | pronounce = | field = | symptoms = [[Fatigue]], [[insomnia]], [[migraines]], [[headache]], and [[dizziness]].<ref name=statpearls>{{cite book|first1=Damilola|last1=Ashorobi|first2=Pouyan|last2=Gohari|title=Essential Thrombocytosis|url=http://www.ncbi.nlm.nih.gov/books/NBK539709/|publisher=StatPearls Publishing|date= August 6, 2023 |location=Treasure Island (FL)|pmid=30969531 |via=PubMed}}</ref> | complications = [[Thrombosis]], [[transient ischemic attack]], [[acute coronary syndrome]], [[Budd–Chiari syndrome|Budd-Chiari syndrome]].<ref name=statpearls/> | onset = | duration = | types = | causes = Overproduction of [[Haematopoiesis|hematopoietic cells]], [[Mutation|genetic mutations]].<ref name=statpearls/> | risks = | diagnosis = Clinical criteria. | differential = [[Chronic myelogenous leukemia]], [[myelodysplastic syndrome]], [[polycythemia vera]], [[primary myelofibrosis]], [[secondary thrombocytosis]].<ref name=statpearls/> | prevention = | treatment = [[Low dose aspirin|Low-dose aspirin]], plateletpheresis, cytoreductive therapy.<ref name=statpearls/> | medication = | prognosis = Median survival is 18 years.<ref name=statpearls/> | frequency = 0.6-2.5/100,000 cases per year.<ref name="emerg"/> | deaths = }} In [[hematology]], '''essential thrombocythemia''' ('''ET''') is a rare chronic blood cancer ([[myeloproliferative neoplasm]]) characterised by the [[thrombocythemia|overproduction]] of [[platelets]] (thrombocytes) by [[megakaryocyte]]s in the [[bone marrow]].<ref name="path" /> It may, albeit rarely, develop into [[acute myeloid leukemia]] or [[myelofibrosis]].<ref name="path" /> It is one of the blood cancers wherein the bone marrow produces too many [[White blood cell|white]] or [[red blood cells]], or platelets.<ref name="path">{{cite journal |last1=Beer |first1=PA |last2=Green |first2=AR |title= Pathogenesis and management of essential thrombocythemia|journal=Hematology |volume=2009 |date=2009 |pages=621–628 |doi=10.1182/asheducation-2009.1.621 |pmid=20008247 |doi-access=free }}</ref>
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