Editing Fatigue (section)

{{Short description|State of tiredness, exhaustion or loss of energy}}
{{About|the medical term|other uses|Fatigue (disambiguation)}}
{{Distinguish|Muscle weakness|Lethargy}}
{{cs1 config|name-list-style=vanc}}
{{Infobox medical condition
| name = Fatigue
| synonyms = Exhaustion, weariness, tiredness, lethargy, listlessness
| image = Cfs_woman_sketch.jpg
| caption = Artistic representation of [[ME/CFS]]
| treatment = Avoid known stressors and unhealthy habits ([[Substance abuse|drug use]], [[excessive alcohol consumption]], smoking), healthy diet, exercise regularly, [[medication]], [[Drinking|hydration]], and [[vitamins]]
}}

'''Fatigue''' is a state of '''tiredness''' (which is not sleepiness), '''exhaustion'''<ref name="NHS">{{cite web |title=10 medical reasons for feeling tired |url=https://www.nhs.uk/live-well/sleep-and-tiredness/10-medical-reasons-for-feeling-tired/ |website=nhs.uk |access-date=24 November 2021 |language=en |date=3 October 2018 |archive-date=24 November 2021 |archive-url=https://web.archive.org/web/20211124143619/https://www.nhs.uk/live-well/sleep-and-tiredness/10-medical-reasons-for-feeling-tired/ |url-status=live }}</ref> or loss of energy.<ref name="Mayo-Clinic-Fatigue-2023">{{cite web |url=https://www.mayoclinic.org/symptoms/fatigue/basics/definition/sym-20050894 | title=Fatigue | website=[[Mayo Clinic]] | access-date=2023-01-06 | archive-date=2023-01-06 | archive-url=https://web.archive.org/web/20230106193733/https://www.mayoclinic.org/symptoms/fatigue/basics/definition/sym-20050894 | url-status=live }}</ref><ref name="Cancer-terms-2023">{{Cite web |url=https://www.cancer.gov/publications/dictionaries/cancer-terms/def/fatigue#:~:text=(fuh%2DTEEG),may%20be%20acute%20or%20chronic |title=Cancer terms |access-date=2023-01-06 |archive-date=2023-01-06 |archive-url=https://web.archive.org/web/20230106193733/https://www.cancer.gov/publications/dictionaries/cancer-terms/def/fatigue#:~:text=(fuh%2DTEEG),may%20be%20acute%20or%20chronic |url-status=live }}</ref> It is a [[signs and symptoms|symptom]] of any of various [[disease]]s; it is not a disease in itself.

Fatigue (in the medical sense) is sometimes associated with medical conditions including [[autoimmune disease]], [[organ failure]], [[chronic pain]] conditions, [[mood disorder]]s, [[heart disease]], [[infectious disease]]s, and post-infectious-disease states.<ref name="pmid23892338">{{cite journal |vauthors=Finsterer J, Mahjoub SZ |title=Fatigue in healthy and diseased individuals |journal=Am J Hosp Palliat Care |volume=31 |issue=5 |pages=562–575 |date=August 2014 |pmid=23892338 |doi=10.1177/1049909113494748 |s2cid=12582944 |url=}}</ref> However, fatigue is complex and in up to a third of primary care cases no medical or psychiatric diagnosis is found.<ref name="BMJ-Best-Practice-2023" /><ref name="Medically unexplained symptoms-2017">{{cite web |url=https://www.nhs.uk/conditions/medically-unexplained-symptoms/ | title=Medically unexplained symptoms | date=19 October 2017 | access-date=6 January 2023 | archive-date=29 September 2017 | archive-url=https://web.archive.org/web/20170929113241/http://www.nhs.uk/conditions/medically-unexplained-symptoms/Pages/Somatisation.aspx | url-status=live }}</ref><ref name="pmid31574939">{{cite journal |vauthors=Haß U, Herpich C, Norman K |title=Anti-Inflammatory Diets and Fatigue |journal=Nutrients |volume=11 |issue=10 |date=September 2019 |page=2315 |pmid=31574939 |pmc=6835556 |doi=10.3390/nu11102315 |url=|doi-access=free }}</ref>

Fatigue (in the general usage sense of normal tiredness) often follows prolonged physical or mental activity. Physical fatigue results from [[muscle fatigue]] brought about by intense [[physical activity]].<ref>{{cite journal | vauthors = Gandevia SC | title = Some central and peripheral factors affecting human motoneuronal output in neuromuscular fatigue | journal = Sports Medicine | volume = 13 | issue = 2 | pages = 93–98 | date = February 1992 | pmid = 1561512 | doi = 10.2165/00007256-199213020-00004 | s2cid = 20473830 }}</ref><ref>{{cite journal | vauthors = Hagberg M | title = Muscular endurance and surface electromyogram in isometric and dynamic exercise | journal = Journal of Applied Physiology | volume = 51 | issue = 1 | pages = 1–7 | date = July 1981 | pmid = 7263402 | doi = 10.1152/jappl.1981.51.1.1 }}</ref><ref>{{cite journal | vauthors = Hawley JA, Reilly T | title = Fatigue revisited | journal = Journal of Sports Sciences | volume = 15 | issue = 3 | pages = 245–246 | date = June 1997 | pmid = 9232549 | doi = 10.1080/026404197367245 }}</ref> Mental fatigue results from prolonged periods of [[Cognition|cognitive]] activity which impairs cognitive ability, can manifest as [[sleepiness]], [[lethargy]], or [[directed attention fatigue]],<ref name="Marcora 2009 857–864">{{cite journal | vauthors = Marcora SM, Staiano W, Manning V | title = Mental fatigue impairs physical performance in humans | journal = Journal of Applied Physiology | volume = 106 | issue = 3 | pages = 857–864 | date = March 2009 | pmid = 19131473 | doi = 10.1152/japplphysiol.91324.2008 | citeseerx = 10.1.1.557.3566 | s2cid = 12221961 }}</ref> and can also impair physical performance.<ref name="Martin">{{cite journal |vauthors=Martin K, Meeusen R, Thompson KG, Keegan R, Rattray B |title=Mental Fatigue Impairs Endurance Performance: A Physiological Explanation |journal=Sports Med |volume=48 |issue=9 |pages=2041–2051 |date=September 2018 |pmid=29923147 |doi=10.1007/s40279-018-0946-9 |s2cid=49317682 |url=}}</ref>