Editing GTPase (section)

{{Short description|Class of enzymes}}
'''GTPases''' are a large family of [[hydrolase]] [[enzyme]]s that bind to the [[nucleotide]] [[Guanosine triphosphate|guanosine triphosphate (GTP)]] and [[hydrolysis|hydrolyze]] it to [[Guanosine diphosphate|guanosine diphosphate (GDP)]].<ref name="pmid8462668">{{cite journal |last1=Stouten |first1=PF |last2=Sander |first2=C |last3=Wittinghofer |first3=A |last4=Valencia |first4=A |date=1993 |title=How does the switch II region of G-domains work? |journal=FEBS Letters |volume=320 |issue=1 |pages=1–6 |doi=10.1016/0014-5793(93)81644-f |pmid=8462668 |doi-access= }}</ref> The GTP binding and hydrolysis takes place in the highly [[Conserved sequence|conserved]] [[P-loop]] "G domain", a [[domain (protein)|protein domain]] common to many GTPases.<ref name="pmid8462668"/>