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Germ cell tumor
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{{Infobox medical condition (new) | name = Germ-cell tumor | synonyms = | image = Seminoma high mag.jpg | caption = [[Micrograph]] of a [[seminoma]], a common germ cell tumor. | pronounce = | field = [[Oncology]] | symptoms = | complications = | onset = | duration = | types = | causes = | risks = | diagnosis = | differential = | prevention = | treatment = | medication = | prognosis = | frequency = | deaths = }} A '''germ cell tumor''' ('''GCT''') is a [[neoplasm]] derived from [[Primordial germ cell|primordial germ cells]].<ref>{{Cite book |title=Harrison's principles of internal medicine |date=2022 |publisher=McGraw Hill |isbn=978-1-264-26850-4 |edition=21st |location=New York |pages=690}}</ref> Germ-cell tumors can be [[cancer]]ous or [[benign tumor|benign]]. Germ cell tumors typically originate from the [[gonads]] ([[ovary]]<ref>{{cite journal | vauthors = Maoz A, Matsuo K, Ciccone MA, Matsuzaki S, Klar M, Roman LD, Sood AK, Gershenson DM | display-authors = 6 | title = Molecular Pathways and Targeted Therapies for Malignant Ovarian Germ Cell Tumors and Sex Cord-Stromal Tumors: A Contemporary Review | journal = Cancers | volume = 12 | issue = 6 | page = 1398 | date = May 2020 | pmid = 32485873 | pmc = 7353025 | doi = 10.3390/cancers12061398 | doi-access = free }}</ref> and [[testis]]), but can arise in other areas of the body. Extragonadal GCTs are thought to result from abnormal migration of germ cell precursors during [[Developmental biology|development]] of the [[embryo]].<ref>{{cite journal| author=Glenn, OA and Barkovich AJ | title= Intracranial germ cell tumors: a comprehensive review of proposed embryologic derivation. | journal=Pediatric Neurosurgery | year=1996 | volume=24 | issue= 5 | pages= 242β251 | pmid=8933567 | doi=10.1159/000121046 | url=https://pubmed.ncbi.nlm.nih.gov/8933567/ }}</ref>
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