Editing Group transfer reaction (section)

In organic chemistry, a '''group transfer reaction''' is a class of the [[Pericyclic reaction|pericyclic]] reaction where one or more groups of atoms is transferred from one molecule to another. Group transfer reactions can sometimes be difficult to identify when separate reactant molecules combine into a single product molecule (like in the ene reaction). Unlike other pericyclic reaction classes, group transfer reactions do not have a specific conversion of pi bonds into sigma bonds or vice versa, and tend to be less frequently encountered. Like all pericyclic reactions, group transfer reactions must obey the [[Woodward–Hoffmann rules]].<ref>{{Cite book |last1=Singh |first1=Jagdamba |title=Photochemistry And Pericyclic Reactions |last2=Simha |first2=Jaya |publisher=New Age International |year=2005 |isbn=9788122416947 |pages=135–139}}</ref> Group transfer reactions can be divided into two distinct subcategories: the ene reaction and the diimide reduction.<ref name=":0">{{Citation |last=Dinda |first=Biswanath |chapter=General Aspects of Pericyclic Reactions |title=Essentials of Pericyclic and Photochemical Reactions |date=2016-11-19 |url=http://dx.doi.org/10.1007/978-3-319-45934-9_1 |series=Lecture Notes in Chemistry |volume=93 |pages=3–11 |access-date=2023-11-05 |place=Cham |publisher=Springer International Publishing |doi=10.1007/978-3-319-45934-9_1 |isbn=978-3-319-45933-2|url-access=subscription }}</ref> Group transfer reactions have diverse applications in various fields, including protein adenylation, biocatalytic and chemoenzymatic approaches for chemical synthesis, and strengthening skim natural rubber latex.<ref name=":1">{{Cite journal |last1=Wimmer |first1=Mary J. |last2=Rose |first2=Irwin A. |date=June 1978 |title=Mechanisms of Enzyme-Catalyzed Group Transfer Reactions |url=https://www.annualreviews.org/doi/10.1146/annurev.bi.47.070178.005123 |journal=Annual Review of Biochemistry |language=en |volume=47 |issue=1 |pages=1031–1078 |doi=10.1146/annurev.bi.47.070178.005123 |pmid=354490 |issn=0066-4154|url-access=subscription }}</ref><ref name=":2">{{Cite journal |last1=Hedberg |first1=Christian |last2=Itzen |first2=Aymelt |date=2015-01-16 |title=Molecular Perspectives on Protein Adenylylation |url=https://pubs.acs.org/doi/10.1021/cb500854e |journal=ACS Chemical Biology |language=en |volume=10 |issue=1 |pages=12–21 |doi=10.1021/cb500854e |pmid=25486069 |issn=1554-8929|doi-access=free |url-access=subscription }}</ref><ref name=":3">{{Cite journal |last1=Toogood |first1=Helen S. |last2=Scrutton |first2=Nigel S. |date=2018-04-06 |title=Discovery, Characterization, Engineering, and Applications of Ene-Reductases for Industrial Biocatalysis |journal=ACS Catalysis |language=en |volume=8 |issue=4 |pages=3532–3549 |doi=10.1021/acscatal.8b00624 |issn=2155-5435 |pmc=6542678 |pmid=31157123}}</ref><ref name=":4">{{Cite journal |last1=Simma |first1=Khosit |last2=Rempel |first2=Garry L. |last3=Prasassarakich |first3=Pattarapan |date=2009-11-01 |title=Improving thermal and ozone stability of skim natural rubber by diimide reduction |url=https://www.sciencedirect.com/science/article/pii/S0141391009002766 |journal=Polymer Degradation and Stability |volume=94 |issue=11 |pages=1914–1923 |doi=10.1016/j.polymdegradstab.2009.08.005 |issn=0141-3910|url-access=subscription }}</ref>