Editing High-throughput screening (section)

{{Short description|Drug discovery technique}}
[[File:Chemical Genomics Robot.jpg|thumb|300px|High-throughput screening robots]]
'''High-throughput screening''' ('''HTS''') is a method for scientific discovery especially used in [[drug discovery]] and relevant to the fields of [[biology]], [[materials science]]<ref>{{cite journal |last1=Zhao |first1=Yicheng |last2=Heumueller |first2=Thomas |last3=Zhang |first3=Jiyun |last4=Luo |first4=Junsheng |last5=Kasian |first5=Olga |last6=Langner |first6=Stefan |last7=Kupfer |first7=Christian |last8=Liu |first8=Bowen |last9=Zhong |first9=Yu |last10=Elia |first10=Jack |last11=Osvet |first11=Andres |last12=Wu |first12=Jianchang |last13=Liu |first13=Chao |last14=Wan |first14=Zhongquan |last15=Jia |first15=Chunyang |last16=Li |first16=Ning |last17=Hauch |first17=Jens |last18=Brabec |first18=Christoph J. |title=A bilayer conducting polymer structure for planar perovskite solar cells with over 1,400 hours operational stability at elevated temperatures |journal=Nature Energy |date=16 December 2021 |volume=7 |issue=2 |pages=144–152 |doi=10.1038/s41560-021-00953-z |bibcode=2022NatEn...7..144Z |s2cid=245285868 |language=en |issn=2058-7546}}</ref> and [[chemistry]].<ref>Inglese J and Auld DS. (2009) Application of High Throughput Screening (HTS) Techniques: Applications in Chemical Biology in Wiley Encyclopedia of Chemical Biology (Wiley & Sons, Inc., Hoboken, NJ) Vol 2, pp 260–274  doi/10.1002/9780470048672.wecb223.</ref><ref>{{cite journal | title = Impact of high-throughput screening in biomedical research |author1 = Macarron, R. |author2 = Banks, M.N.|author3 = Bojanic, D.| author4 = Burns, D.J.|author5 = Cirovic, D.A.|author6 = Garyantes, T.|author7 = Green, D.V.| author8 = Hertzberg, R.P. |author9 = Janzen, W.P.|author10 = Paslay, J.W.|author11 = Schopfer, U.| author12 = Sittampalam, G.S. | journal = Nat Rev Drug Discov|date = 2011 |volume = 10|issue = 3 |pages = 188–195|pmid = 21358738 | doi = 10.1038/nrd3368|s2cid = 205477370 }}</ref> Using [[robotics]], data processing/control software, liquid handling devices, and sensitive detectors, high-throughput screening allows a researcher to quickly conduct millions of chemical, genetic, or pharmacological tests. Through this process one can quickly recognize active compounds, antibodies, or genes that modulate a particular biomolecular pathway. The results of these experiments provide starting points for drug design and for understanding the noninteraction or role of a particular location.