Editing Hyperchloremia (section)

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| caption         = [[Chlorine]]
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'''Hyperchloremia''' is an [[electrolyte disturbance]] in which there is an elevated level of [[chloride]] ions in the [[blood]].<ref name="pmid9760315">{{cite journal|date=October 1998|title=Effects of hyperchloremia on blood oxygen binding in healthy calves|journal=J. Appl. Physiol.|volume=85|issue=4|pages=1267–72|doi=10.1152/jappl.1998.85.4.1267|pmid=9760315|vauthors=Cambier C, Detry B, Beerens D, etal|s2cid=1778217}}</ref> The normal serum range for chloride is 96 to 106 [[equivalent (chemistry)|mEq/L]],<ref name=":3">{{Cite web|url=https://medlineplus.gov/ency/article/003485.htm|title=Chloride test - blood: MedlinePlus Medical Encyclopedia|website=medlineplus.gov|language=en|access-date=2017-12-12}}</ref> therefore chloride levels at or above 110 mEq/L usually indicate [[kidney]] dysfunction as it is a regulator of chloride concentration.<ref name=":6" /> As of now there are no specific symptoms of hyperchloremia; however, it can be influenced by multiple abnormalities that cause a loss of electrolyte-free fluid,  loss of hypotonic fluid, or increased administration of [[sodium chloride]]. These abnormalities are caused by [[diarrhea]], [[vomiting]], increased sodium chloride intake, [[Kidney failure|renal dysfunction]], [[diuretic]] use, and [[Diabetes insipidus|diabetes]]. Hyperchloremia should not be mistaken for hyperchloremic metabolic acidosis as hyperchloremic metabolic acidosis is characterized by two major changes: a decrease in blood [[pH]] and [[bicarbonate]] levels, as well as an increase in blood chloride levels.<ref name=":6">{{Cite web |url=https://www.dynamed.com/topics/dmp~AN~T115404/Hyperchloremic-metabolic-acidosis |title=Hyperchloremic metabolic acidosis |website=dynamed.com |access-date=2017-12-12 |archive-date=2019-02-13 |archive-url=https://web.archive.org/web/20190213005648/https://www.dynamed.com/topics/dmp~AN~T115404/Hyperchloremic-metabolic-acidosis |url-status=dead }}</ref> Instead those with hyperchloremic metabolic acidosis are usually predisposed to hyperchloremia.

Hyperchloremia prevalence in hospital settings has been researched in the medical field since one of the major sources of treatment at hospitals is administering [[Saline (medicine)|saline solution]].  Previously, animal models with elevated chloride have displayed more inflammation markers, changes in [[blood pressure]], increased [[Renal function|renal]] [[vasoconstriction]], and less renal blood flow as well at glomerulus filtration, all of which are prompting researchers to investigate if these changes or others may exist in patients. Some studies have reported a possible relationship between increased chloride levels and death or [[acute kidney injury]] in severely ill patients that may frequent the hospital or have prolonged visits. There are other studies that have found no relationship.<ref name=":2" />