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Inotrope
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{{short description|Agent that alters the strength of muscular contractions}} {{More citations needed|date=March 2023}} {{distinguish|ionotropic}} An '''inotrope'''{{refn|name=help|group=help|The word ''inotrope'' is [[international scientific vocabulary|ISV]] via [[Neo-Latin]], from Greek ''in''-, fibre or sinew, plus ''[[wikt:-trope|-trope]]'', turning or moving. The prevalent pronunciations are {{IPAc-en|ˈ|aɪ|n|ə|t|r|oʊ|p|,_|-|n|oʊ|t|-}}<ref name="MW_Collegiate">{{cite web | title = Inotrope | work = Merriam-Webster's Collegiate Dictionary | publisher = Merriam-Webster | url = http://unabridged.merriam-webster.com/collegiate/ | access-date = 2015-02-10 | archive-date = 2020-10-10 | archive-url = https://web.archive.org/web/20201010163505/https://unabridged.merriam-webster.com/subscriber/login?redirect_to=%2Fcollegiate%2F | url-status = dead }}</ref><ref name="AHD">{{cite web | title = Inotrope | work = The American Heritage Dictionary of the English Language |publisher=Houghton Mifflin Harcourt |url=https://ahdictionary.com/ }}</ref> and {{IPAc-en|ˈ|ɪ|n|-}},<ref name="Dorlands">{{cite web | title = Inotrope | work = Dorland's Illustrated Medical Dictionary | publisher = Elsevier | url = http://dorlands.com/ | access-date = 2015-02-10 | archive-date = 2014-01-11 | archive-url = https://web.archive.org/web/20140111192614/http://dorlands.com/ | url-status = dead }}</ref><ref name="Stedmans">{{cite web | title = Inotrope | work = Stedman's Medical Dictionary |publisher=Wolters Kluwer |url=http://stedmansonline.com/ }}</ref> with {{IPAc-en|ˈ|iː|n|-}}<ref name="AHD"/><ref name="MW_Medical">{{cite web | title = Inotrope | work = Merriam-Webster's Medical Dictionary |url=https://www.merriam-webster.com/dictionary/inotrope#:~:text=ino·%E2%80%8Btrope%20ˈī%2Dn%C9%99,epinephrine%20or%20a%20beta%2Dblocker) }}</ref> being less common.}} or '''inotropic''' is a [[drug]] or any substance that alters the force or energy of [[muscular contraction]]s. Negatively inotropic agents weaken the force of [[muscle|muscular]] contractions. Positively inotropic agents increase the strength of muscular contraction. The term '''''inotropic state''''' is most commonly used in reference to various [[medication|drugs]] that affect the strength of [[myocardial contractility|contraction of heart muscle]]. However, it can also refer to [[pathological]] conditions. For example, [[ventricular hypertrophy|enlarged heart muscle]] can increase inotropic state, whereas [[myocardial infarction|dead heart muscle]] can decrease it.
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