Editing Integrase (section)

{{Short description|Class of enzymes}}
{{Infobox protein family
| Symbol = Integrase_Zn
| Name = Integrase Zinc binding domain
| image = PDB 1wjd EBI.jpg
| width = 
| caption = solution structure of the N-terminal Zn binding domain of HIV-1 integrase (e form), NMR, 38 structures
| Pfam = PF02022
| Pfam_clan =  
| InterPro = IPR003308
| SMART = 
| PROSITE = 
| MEROPS = 
| SCOP = 1wjb
| TCDB = 
| OPM family = 
| OPM protein = 
| CAZy = 
| CDD = 
}}
{{Infobox protein family
| Symbol = rve
| Name = Integrase core domain
| image = PDB 1c1a EBI.jpg
| width = 
| caption = Crystal structure of the RSV two-domain integrase.
| Pfam = PF00665
| Pfam_clan = CL0219 
| InterPro = IPR001584
| SMART = 
| PROSITE = 
| MEROPS = 
| SCOP = 2itg
| TCDB = 
| OPM family = 
| OPM protein = 
| CAZy = 
| CDD = 
}}
{{Infobox protein family
| Symbol = IN_DBD_C
| Name = Integrase DNA binding domain
| image = PDB 1c1a EBI.jpg
| width = 
| caption = Crystal structure of the RSV two-domain integrase.
| Pfam = PF00552
| Pfam_clan =  
| InterPro = IPR001037
| SMART = 
| PROSITE = 
| MEROPS = 
| SCOP = 1ihw
| TCDB = 
| OPM family = 
| OPM protein = 
| CAZy = 
| CDD = 
}}
'''Retroviral integrase''' ('''IN''') is an [[enzyme]] produced by a [[retrovirus]] (such as [[HIV]]) that [[Retroviral integration|integrates]] (forms [[Covalent bond|covalent]] links between) its genetic information into that of the host [[Cell (biology)|cell]] it infects.<ref>{{cite book | vauthors = Beck BJ, Freudenreich O, Worth JL | chapter = Patients with Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome |date=2010 | doi = 10.1016/b978-1-4377-1927-7.00026-1 |title = Massachusetts General Hospital Handbook of General Hospital Psychiatry |pages=353–370 |publisher=Elsevier | isbn = 9781437719277 }}</ref> Retroviral INs are not to be confused with [[phage integrase]]s ([[recombinases]]) [[Site-specific recombinase technology|used in biotechnology]], such as [[Lambda phage|λ phage]] integrase, as discussed in [[site-specific recombination]].

The [[Biomolecular complex|macromolecular complex]] of an IN [[macromolecule]] bound to the ends of the viral DNA ends has been referred to as the ''[[wiktionary:intasome#:~:text=Noun,a bacteriophage into a host.|intasome]]''; IN is a key component in this and the retroviral [[pre-integration complex]].<ref>{{cite journal | vauthors = Masuda T | title = Non-Enzymatic Functions of Retroviral Integrase: The Next Target for Novel Anti-HIV Drug Development | journal = Frontiers in Microbiology | volume = 2 | pages = 210 | date = 2011 | pmid = 22016749 | doi = 10.3389/fmicb.2011.00210 | pmc = 3192317 | doi-access = free }}</ref>