Editing Integrin (section)

{{Short description|Instance of a defined set in Homo sapiens with Reactome ID (R-HSA-374573)}}
{{stack|
{{Infobox protein family
| Symbol = Integrin_alphaVbeta3
| Name = Integrin alphaVbeta3 extracellular domains
| image = PDB 1jv2 EBI.jpg
| width =
| caption = Structure of the extracellular segment of integrin alpha Vbeta3.<ref name="pmid11546839">{{cite journal | vauthors = Xiong JP, Stehle T, Diefenbach B, Zhang R, Dunker R, Scott DL, Joachimiak A, Goodman SL, Arnaout MA | title = Crystal structure of the extracellular segment of integrin alpha Vbeta3 | journal = Science | volume = 294 | issue = 5541 | pages = 339–45 | date = October 2001 | pmid = 11546839 | pmc = 2885948 | doi = 10.1126/science.1064535 | bibcode = 2001Sci...294..339X }}</ref>
| Pfam = PF08441
| Pfam_clan = CL0159
| InterPro = IPR013649
| SMART =
| PROSITE =
| SCOP = 1jv2
| TCDB =
| OPM family = 176
| OPM protein = 2knc
| PDB = 
| Membranome superfamily = 13
}}
{{Infobox protein family
| Symbol = Integrin_alpha
| Name = Integrin alpha cytoplasmic region
| image = PDB 1dpk EBI.jpg
| width =
| caption = Structure of chaperone protein PAPD.<ref name="pmid10446050">{{cite journal | vauthors = Sauer FG, Fütterer K, Pinkner JS, Dodson KW, Hultgren SJ, Waksman G | title = Structural basis of chaperone function and pilus biogenesis | journal = Science | volume = 285 | issue = 5430 | pages = 1058–61 | date = August 1999 | pmid = 10446050 | doi = 10.1126/science.285.5430.1058 }}</ref>
| Pfam = PF00357
| InterPro = IPR000413
| SMART =
| PROSITE = PDOC00215
| SCOP = 1dpk
| TCDB =
| OPM family = 
| OPM protein =
| PDB = 
}}
{{Infobox protein family
| Symbol = Integrin_beta
| Name = Integrin, beta chain (vWA)
| image =Integrinalpha.png
| width =
| caption =
| Pfam = PF00362
| InterPro = IPR002369
| SMART = SM00187
| PROSITE = PDOC00216
| SCOP = 1jv2
| TCDB =
| OPM family =
| OPM protein =
| PDB = {{PDB2|1jv2}}, {{PDB2|1kup}}, {{PDB2|1kuz}}, {{PDB2|1l3y}}, {{PDB2|1l5g}}, {{PDB2|1m1x}}, {{PDB2|1m8o}}, {{PDB2|1s4x}}, {{PDB2|1txv}}, {{PDB2|1ty3}}, {{PDB2|1ty5}}, {{PDB2|1ty6}}, {{PDB2|1ty7}}, {{PDB2|1tye}}, {{PDB2|1u8c}}
}}
{{Infobox protein family
| Symbol = Integrin_b_cyt
| Name = Integrin beta 7 cytoplasmic domain: complex with filamin
| image = PDB 2brq EBI.jpg
| width = 
| caption = crystal structure of the filamin a repeat 21 complexed with the integrin beta7 cytoplasmic tail peptide
| Pfam = PF08725
| Pfam_clan =  
| InterPro = IPR014836
| SMART = 
| PROSITE = 
| MEROPS = 
| SCOP = 1m8O
| TCDB = 
| OPM family = 
| OPM protein = 
| CAZy = 
| CDD = 
}}}}
'''Integrins''' are [[transmembrane receptors]] that help cell–cell and cell–[[extracellular matrix]] (ECM) adhesion.<ref name="pmid12297042">{{cite journal | vauthors = Hynes RO | title = Integrins: bidirectional, allosteric signaling machines | journal = Cell | volume = 110 | issue = 6 | pages = 673–87 | date = September 2002 | pmid = 12297042 | doi = 10.1016/s0092-8674(02)00971-6 | s2cid = 30326350 | doi-access = free }}</ref> Upon ligand binding, integrins activate [[signal transduction]] pathways that mediate cellular signals such as regulation of the [[cell cycle]], organization of the intracellular [[cytoskeleton]], and movement of new receptors to the cell membrane.<ref>{{cite journal | vauthors = Giancotti FG, Ruoslahti E | title = Integrin signaling | journal = Science | volume = 285 | issue = 5430 | pages = 1028–32 | date = August 1999 | pmid = 10446041 | doi = 10.1126/science.285.5430.1028 }}</ref> The presence of integrins allows rapid and flexible responses to events at the cell surface (''e.g''. signal [[platelet]]s to initiate an interaction with [[coagulation]] factors).

Several types of integrins exist, and one cell generally has multiple different types on its surface. Integrins are found in all animals while [[integrin-like receptors]] are found in plant cells.<ref name="pmid12297042"/>

Integrins work alongside other proteins such as [[cadherin]]s, the [[immunoglobulin superfamily]] [[cell adhesion molecule]]s, [[selectin]]s and [[syndecan]]s, to mediate cell–cell and cell–matrix interaction. [[Ligands]] for integrins include [[fibronectin]], [[vitronectin]], [[collagen]] and [[laminin]].