Editing Interactome (section)

{{Short description|Complete set of molecular interactions in a biological cell}}
In [[molecular biology]], an '''interactome''' is the whole set of molecular interactions in a particular [[Cell (biology)|cell]]. The term specifically refers to physical interactions among molecules (such as those among proteins, also known as [[protein–protein interaction]]s, PPIs; or between small molecules and proteins<ref>Wang L, Eftekhari P, Schachner D, Ignatova ID, Palme V, Schilcher N, Ladurner A, Heiss EH, Stangl H, Dirsch VM, Atanasov AG. [https://www.ncbi.nlm.nih.gov/pubmed/30038271 Novel interactomics approach identifies ABCA1 as direct target of evodiamine, which increases macrophage cholesterol efflux]. Sci Rep. 2018 Jul 23;8(1):11061. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056500/ doi: 10.1038/s41598-018-29281-1].</ref>) but can also describe sets of indirect interactions among genes ([[genetic interactions]]). [[File:Network of how 100 of the 528 genes identified with significant differential expression relate to DISC1 and its core interactors.png|400px|right|thumb|Part of the [[DISC1]] interactome with genes represented by text in boxes and interactions noted by lines between the genes. From Hennah and Porteous, 2009.<ref name="pmid19300510">{{cite journal |vauthors=Hennah W, Porteous D|title=The DISC1 pathway modulates expression of neurodevelopmental, synaptogenic and sensory perception genes |journal=PLOS ONE |volume=4 |issue=3 |pages=e4906 |year=2009 |pmid=19300510 |pmc=2654149 |doi=10.1371/journal.pone.0004906 |editor1-last=Reif |editor1-first=Andreas|bibcode=2009PLoSO...4.4906H |doi-access=free }} {{open access}}</ref>]]
The word "interactome" was originally coined in 1999 by a group of French scientists headed by Bernard Jacq.<ref name="pmid9847149">{{cite journal |author=Sanchez C |title=Grasping at molecular interactions and genetic networks in Drosophila melanogaster using FlyNets, an Internet database |journal=Nucleic Acids Res. |volume=27 |issue=1 |pages=89–94 |date=January 1999 |pmid=9847149 |pmc=148104 |doi= 10.1093/nar/27.1.89|author2= Lachaize C |author3= Janody F |display-authors=etal}}</ref> Mathematically, interactomes are generally displayed as [[Graph (discrete mathematics)|graphs]]. While interactomes may be described as [[biological network]]s, they should not be confused with other networks such as [[neural network]]s or [[food web]]s.