Editing Mumps (section)

{{short description|Human disease caused by paramyxovirus}}
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{{Use dmy dates|date=October 2020}}
{{Use American English|date=October 2020}}
{{Infobox medical condition (new)
| name = Mumps
| synonyms = Epidemic parotitis
| field = [[Infectious disease (medical specialty)|Infectious disease]]
| image = Mumps PHIL 130 lores.jpg
| caption = Child with mumps showing characteristic facial swelling
| symptoms = Parotitis and non-specific symptoms such as fever, headache, malaise, muscle pain, and loss of appetite
| complications = Deafness, inflammatory conditions such as orchitis, oophoritis, and pancreatitis, and rarely sterility
| onset = 7–25 days after exposure
| duration = Usually less than two weeks
| causes = [[Mumps virus]]
| risks = Exposure to someone with mumps
| diagnosis = Antibody testing, viral cultures, and reverse transcription polymerase chain reaction
| differential =
| prevention = [[Mumps vaccine]]
| treatment = [[Supportive treatment|Supportive]]
| medication = [[Analgesic|Pain medication]], [[intravenous immunoglobulin]]
| prognosis = Usually excellent; case fatality rate of 1.6–3.8 people per 10,000 pre vaccination. (USA, 1966-1975) <ref name="GalazkaMumps1999">{{cite journal
 | last1       = Galazka
 | first1      = A. M.
 | last2       = Robertson
 | first2      = S. E.
 | last3       = Kraigher
 | first3      = A.
 | title       = Mumps and mumps vaccine: a global review
 | journal     = Bulletin of the World Health Organization
 | date        = January 1999
 | volume      = 77
 | issue       = 1
 | pages       = 3–14
 | pmid        = 10063655
 | pmc         = 2557572
 | url         = https://pmc.ncbi.nlm.nih.gov/articles/PMC2557572/
}}</ref> <ref name=rubin />
| frequency = 385,000+ (387,529 reported) (2023) <ref name='WHOMumpsCases'>{{cite web | title=Detail Page | website=Immunization Data | url=https://immunizationdata.who.int/global/wiise-detail-page/mumps-reported-cases-and-incidence?CODE=Global&YEAR= | access-date=2025-01-26}}</ref> 
}}

'''Mumps''' is a highly contagious [[viral disease]] caused by the [[mumps virus]].<ref>{{Cite web |title=Mumps |url=https://www.who.int/teams/health-product-policy-and-standards/standards-and-specifications/vaccine-standardization/mumps |access-date=2024-05-10 |website=www.who.int |language=en}}</ref> Initial symptoms of mumps are non-specific and include fever, headache, malaise, [[muscle]] pain, and loss of appetite. These symptoms are usually followed by painful [[Edema|swelling]] around the side of the face (the [[parotid gland]]s, called [[parotitis]]), which is the most common symptom of a mumps infection. Symptoms typically occur 16 to 18 days after exposure to the virus. About one-third of people with a mumps infection do not have any symptoms (asymptomatic).

Complications are rare but include [[deafness]] and a wide range of inflammatory conditions, of which inflammation of the [[Testicle|testes]], [[breast]]s, [[Ovary|ovaries]], [[pancreas]], [[meninges]], and [[brain]] are the most common. [[Viral meningitis]] can occur in 1/4 of people with mumps.<ref>{{Cite web |date=2018-03-06 |title=Mumps - Complications |url=https://www.nhs.uk/conditions/mumps/complications/ |access-date=2024-02-09 |website=nhs.uk |language=en}}</ref> Testicular inflammation may result in reduced [[fertility]] and, rarely, [[Sterility (physiology)|sterility]].

Humans are the only natural hosts of the mumps virus. The mumps virus is an [[RNA virus]] in the family ''[[Paramyxoviridae]]''. The virus is primarily transmitted by respiratory secretions such as droplets and saliva, as well as via direct contact with an infected person. Mumps is highly contagious and spreads easily in densely populated settings. Transmission can occur from one week before the onset of symptoms to eight days after. During infection, the virus first infects the upper respiratory tract. From there, it spreads to the salivary glands and [[lymph node]]s. Infection of the lymph nodes leads to the presence of the virus in the blood, which spreads the virus throughout the body. In places where mumps is common, it can be diagnosed based on clinical presentation. In places where mumps is less common, however, laboratory diagnosis using antibody testing, [[viral culture]]s, or real-time [[reverse transcription polymerase chain reaction]] may be needed. 

There is no specific treatment for mumps, so treatment is supportive and includes rest and pain relief. Mumps infection is usually [[Self-limiting (biology)|self-limiting]], coming to an end as the immune system clears the infection. Infection can be prevented with vaccination. The [[MMR vaccine]] is a safe and effective vaccine to prevent mumps infections and is used widely around the world.<ref>{{Cite web |last=CDC |date=2021-03-08 |title=Mumps {{!}} Vaccination {{!}} CDC |url=https://www.cdc.gov/mumps/vaccination.html |access-date=2024-02-09 |website=Centers for Disease Control and Prevention |language=en-us}}</ref> The MMR vaccine also protects against [[measles]] and [[rubella]]. The spread of the disease can also be prevented by isolating infected individuals.

Mumps historically has been a highly prevalent disease, commonly occurring in outbreaks in densely crowded spaces. In the absence of vaccination, infection normally occurs in childhood, most frequently at the ages of 5–9. Symptoms and complications are more common in males and more severe in adolescents and adults. Infection is most common in winter and spring in temperate climates, whereas no seasonality is observed in tropical regions. Written accounts of mumps have existed since ancient times, and the cause of mumps, the mumps virus, was discovered in 1934. By the 1970s, vaccines had been created to protect against infection, and countries that have adopted mumps vaccination have seen a near-elimination of the disease. In the 21st century, however, there has been a resurgence in the number of cases in many countries that vaccinate, primarily among adolescents and young adults, due to multiple factors such as waning vaccine immunity and [[Vaccine hesitancy|opposition to vaccination]].<ref>{{cite journal | last1=Barskey | first1=Albert E. | last2=Glasser | first2=John W. | last3=LeBaron | first3=Charles W. | title=Mumps resurgences in the United States: A historical perspective on unexpected elements | journal=Vaccine | publisher=Elsevier BV | volume=27 | issue=44 | date=2009-10-19 | issn=0264-410X | pmid=19815120 | doi=10.1016/j.vaccine.2009.06.109 | pages=6186–6195}}</ref>