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Prophase
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{{short description|First phase of cell division in both mitosis and meiosis}} [[File:Prophase eukaryotic mitosis.svg|thumb|300px|Prophase is the first step of cell division in mitosis. As it occurs after G2 of interphase, DNA has been already replicated when prophase begins.<ref name="Nussbaum 2016 12–20">{{cite book |title=Thompson & Thompson Genetics in Medicine |vauthors=Nussbaum RL, McInnes RR, Huntington F |publisher=[[Elsevier]] |year=2016 |isbn=9781437706963 |location=Philadelphia |pages=12–20}}</ref>]] [[File:3D-SIM-3 Prophase 3 color.jpg|thumb|right|200px|[[Fluorescence microscope]] image of two mouse cell nuclei in prophase (scale bar is 5 μm).<ref name=":0">{{cite journal |vauthors=Schermelleh L, Carlton PM, Haase S, Shao L, Winoto L, Kner P, Burke B, Cardoso MC, Agard DA, Gustafsson MG, Leonhardt H, Sedat JW |display-authors=6 |title=Subdiffraction multicolor imaging of the nuclear periphery with 3D structured illumination microscopy |journal=[[Science (journal)|Science]] |volume=320 |issue=5881 |pages=1332–36 |date=June 2008 |pmid=18535242 |pmc=2916659 |doi=10.1126/science.1156947 |bibcode=2008Sci...320.1332S}}</ref>]] '''Prophase''' ({{etymology|grc|''[[wikt:προ-|προ-]]'' ([[wikt:pro-|pro-]])|before||''[[wikt:|φάσις]]'' (phásis)|appearance}}) is the first stage of [[cell division]] in both [[mitosis]] and [[meiosis]]. Beginning after [[interphase]], [[DNA]] has already been replicated when the [[Cell (biology)|cell]] enters prophase. The main occurrences in prophase are the condensation of the [[chromatin]] reticulum and the disappearance of the [[nucleolus]].<ref name=":2" />
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