Editing Propylhexedrine (section)

{{Short description|Topical nasal decongestant}}{{good article}}
{{Use dmy dates|date=September 2021}}
{{cs1 config|name-list-style=vanc|display-authors=6}}
{{Infobox drug
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 464217507
| drug_name = Propylhexedrine
| IUPAC_name = (±)-1-cyclohexyl-''N''-methylpropan-2-amine
| image = Propylhexedrine.svg
| image_class = skin-invert-image
| imageL = Propylhex_3d.png
| image_classL = bg-transparent
| widthL = 
| altL = 
| imageR = Propylhex_3d (R).png
| image_classR = bg-transparent
| widthR = 
| altR = 
| captionLR = Left: (''S'')-Propylhexedrine<br/>Right: (''R'')-Propylhexedrine

<!--Clinical data-->| tradename = Benzedrex, Obesin, Dristan Inhaler, and others
| Drugs.com = {{drugs.com|monograph|propylhexedrine}}
| pregnancy_category = C
| legal_AU = S4
| legal_BR = B1
| legal_BR_comment = 
| legal_CA = Unscheduled
| legal_DE = [[Prescription drug|Prescription Only]]
| legal_US = OTC
| legal_UN = Unscheduled
| legal_UK = P
| routes_of_administration = Medical: [[Intranasal]] (inhaler)<br />Recreational: [[By mouth|Oral]], [[parenteral]]

<!--Pharmacokinetic data-->| bioavailability = 
| protein_bound = 
| metabolism = 
| elimination_half-life = 4 ± 1.5 hours
| excretion = <!--Identifiers-->
| index2_label = hydrochloride
| CAS_number_Ref = {{cascite|correct|CAS}}
| CAS_number = 101-40-6
| CAS_number2_Ref = {{cascite|correct|CAS}}
| CAS_number2 = 1007-33-6
| ATC_prefix = N06BA
| ATC_suffix = 
| ATC_supplemental = 
| PubChem = 7558
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB06714
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 7277
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = LQU92IU8LL
| UNII2_Ref = {{fdacite|correct|FDA}}
| UNII2 = 064LUN7NZ5
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D05637
| synonyms = 1-cyclohexyl-2-methylaminopropane
| C = 10
| H = 21
| N = 1
| SMILES = N(C(CC1CCCCC1)C)C
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C10H21N/c1-9(11-2)8-10-6-4-3-5-7-10/h9-11H,3-8H2,1-2H3
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = JCRIVQIOJSSCQD-UHFFFAOYSA-N
| chirality = [[Racemic mixture]]
}}

'''Propylhexedrine''', sold under the brand name '''Benzedrex''' among others, is an [[Psychotropic alkylamines|alkylamine]] primarily utilized as a [[Topical decongestant|topical nasal decongestant]].<ref>{{Cite web |date=June 7, 2023 |title=Cold, Cough, Allergy, Bronchodilator, and Antiasthmatic Drug Products for Over-the-Counter Human Use |url=https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=341.20 |archive-url=https://web.archive.org/web/20230706041627/https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=341.20 |archive-date=6 July 2023 |access-date=July 5, 2023 |website=[[FDA]] }}</ref> Its main indications are relief of congestion due to [[Common cold|colds]], [[Allergy|allergies]], and [[allergic rhinitis]].<ref name="Daily Med">{{Cite web |title=BENZEDREX 09-19-2014- propylhexedrine inhalant |url=https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=03a8ef3c-a808-6208-e054-00144ff8d46c |archive-url=https://archive.today/20230716000914/https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=03a8ef3c-a808-6208-e054-00144ff8d46c |archive-date=July 16, 2023 |access-date=July 15, 2023 |work=Daily Med |publisher=U.S. National Library of Medicine}}</ref> Propylhexedrine was first used medically in 1949, with the release of Benzedrex by [[Smith, Kline & French]], and it has been used, mainly within the United States, since then.<ref name="Schwarez" />