Editing Protein targeting (section)

{{Short description|Biological mechanism for routing proteins}}
'''Protein targeting''' or '''protein sorting''' is the [[Mechanism (biology)|biological mechanism]] by which [[protein]]s are transported to their appropriate destinations within or outside the cell.<ref name="Nelson-2017">{{Cite book| vauthors = Nelson DL | url=https://www.worldcat.org/oclc/986827885|title=Lehninger principles of biochemistry|others=Cox, Michael M.,, Lehninger, Albert L.| date=January 2017|isbn=978-1-4641-2611-6|edition=Seventh|location=New York, NY|oclc=986827885}}</ref><ref name="Lodish, Berk, Kaiser, Krieger, Bretscher, Ploegh, Martin, Yaffe, Amon-2021">{{Cite book |last=Lodish, Berk, Kaiser, Krieger, Bretscher, Ploegh, Martin, Yaffe, Amon |title=Molecular Cell Biology |publisher=W.H. Freeman and Company |year=2021 |isbn=978-1-319-20852-3 |edition=9th |location=New York, NY}}</ref>{{NoteTag|This article deals with protein targeting in [[eukaryote]]s unless specified otherwise}} Proteins can be targeted to the inner space of an [[organelle]], different intracellular [[biological membrane|membrane]]s, the [[cell membrane|plasma membrane]], or to the exterior of the cell via [[secretion]].<ref name="Nelson-2017" /><ref name="Lodish, Berk, Kaiser, Krieger, Bretscher, Ploegh, Martin, Yaffe, Amon-2021" /> Information contained in the protein itself directs this delivery process.<ref name="Lodish, Berk, Kaiser, Krieger, Bretscher, Ploegh, Martin, Yaffe, Amon-2021" /><ref name="Blobel-1975">{{cite journal | vauthors = Blobel G, Dobberstein B | title = Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma | journal = The Journal of Cell Biology | volume = 67 | issue = 3 | pages = 835–51 | date = December 1975 | pmid = 811671 | pmc = 2111658 | doi = 10.1083/jcb.67.3.835 }}</ref> Correct sorting is crucial for the cell; errors or dysfunction in sorting have been linked to multiple diseases.<ref name="Lodish, Berk, Kaiser, Krieger, Bretscher, Ploegh, Martin, Yaffe, Amon-2021" /><ref name="Protein sorting gone wrong--VPS10P">{{cite journal | vauthors = Schmidt V, Willnow TE | title = Protein sorting gone wrong--VPS10P domain receptors in cardiovascular and metabolic diseases | journal = Atherosclerosis | volume = 245 | pages = 194–9 | date = February 2016 | pmid = 26724530 | doi = 10.1016/j.atherosclerosis.2015.11.027 | doi-access = free }}</ref><ref>{{cite journal | vauthors = Guo Y, Sirkis DW, Schekman R | title = Protein sorting at the trans-Golgi network | journal = Annual Review of Cell and Developmental Biology | volume = 30 | issue = 1 | pages = 169–206 | date = 2014-10-11 | pmid = 25150009 | doi = 10.1146/annurev-cellbio-100913-013012 }}</ref>