Editing Pyruvate kinase deficiency (section)

{{Infobox medical condition (new)
| name          = Pyruvate kinase deficiency
| synonyms      = Erythrocyte pyruvate kinase deficiency<ref>{{OMIM|266200}}</ref>
| image         = Phosphoenolpyruvic acid.svg
| caption       = [[Phosphoenolpyruvate]]
| pronounce     =
| symptoms      = Anemia, tachycardia<ref name=:3/>
| complications =
| onset         =
| duration      =
| types         =
| causes        = Mutation in PKLR gene<ref name=hom/>
| risks         =
| diagnosis     = Physical exam, [[Complete blood count|CBC]]<ref name=medl/>
| differential  =
| prevention    =
| treatment     = Blood transfusion<ref name=medl/>
| medication    =
| prognosis     =
| frequency     =
| deaths        =
}}
'''Pyruvate kinase deficiency''' is an [[heredity|inherited]] [[metabolic disorder]] of the enzyme [[pyruvate kinase]] which affects the survival of [[red blood cell]]s.<ref name="medl">{{Cite web|title = Pyruvate kinase deficiency: MedlinePlus Medical Encyclopedia|url = https://www.nlm.nih.gov/medlineplus/ency/article/001197.htm|website = www.nlm.nih.gov|access-date = 2015-11-11}}</ref><ref>{{Cite web|title = Pyruvate kinase deficiency {{!}} Disease {{!}} Overview {{!}} Genetic and Rare Diseases Information Center (GARD) – an NCATS Program|url = https://rarediseases.info.nih.gov/gard/7514/pyruvate-kinase-deficiency/resources/1|website = rarediseases.info.nih.gov|access-date = 2015-11-11|archive-date = 2015-09-05|archive-url = https://web.archive.org/web/20150905112757/https://rarediseases.info.nih.gov/gard/7514/pyruvate-kinase-deficiency/resources/1|url-status = dead}}</ref> Both [[autosome|autosomal]] [[Dominance (genetics)|dominant]] and [[recessive]] inheritance have been observed with the disorder; classically, and more commonly, the inheritance is [[autosomal recessive]]. Pyruvate kinase deficiency is the second most common cause of enzyme-deficient [[hemolytic anemia]], following [[G6PD deficiency]].<ref name=":0">{{Cite journal|last1=Gallagher|first1=Patrick G.|last2=Glader|first2=Bertil|date=2016-05-01|title=Diagnosis of Pyruvate Kinase Deficiency|journal=Pediatric Blood & Cancer|language=en|volume=63|issue=5|pages=771–772|doi=10.1002/pbc.25922|pmid=26836632|s2cid=42964783|issn=1545-5017}}</ref>