Editing Reperfusion injury (section)

{{Short description|Tissue damage after return of blood supply following ischemia or hypoxia}}
{{Infobox medical condition (new)
| name            = Reperfusion injury
| synonyms        =  '''Reperfusion insult'''
| image           = Ischemic preconditioning of the heart.png
| alt             =
| caption         = Native records of contractile activity of the left ventricle of isolated rat heart perfused under [[Langendorff heart|Langendorff technique]]. Curve A – contractile function of the heart is greatly depressed after [[ischemia]]-reperfusion. Curve B – a set of short ischemic episodes ([[ischemic preconditioning]]) before prolonged ischemia provides functional recovery of contractile activity of the heart at reperfusion.
| pronounce       =
| field           =
| geneReviewsID   =
| symptoms        =
| complications   =
| onset           =
| duration        =
| types           =
| causes          =
| risks           =
| diagnosis       =
| differential    =
| prevention      =
| treatment       =
| medication      =
| prognosis       =
| frequency       =
| deaths          =
}}
'''Reperfusion injury''', sometimes called '''ischemia-reperfusion injury''' ('''IRI''') or '''reoxygenation injury''', is the [[tissue (biology)|tissue]] damage caused when [[blood]] supply returns to tissue (''[[wikt:re-#Prefix|re-]]'' + ''[[perfusion]]'') after a period of [[ischemia]] or lack of oxygen (anoxia or [[hypoxia (medical)|hypoxia]]).  The absence of [[oxygen]] and [[nutrient]]s from blood during the ischemic period creates a condition in which the restoration of [[circulatory system|circulation]] results in [[inflammation]] and [[oxidation|oxidative]] damage through the induction of [[oxidative stress]] rather than (or along with) restoration of normal function.

Reperfusion injury is distinct from [[cerebral hyperperfusion syndrome]] (sometimes called "Reperfusion syndrome"), a state of abnormal cerebral vasodilation.