Editing Respiratory complex I (section)

{{Short description|Protein complex involved in cellular respiration}}
[[File:NADH Dehydrogenase Mechanism (Fixed).png|thumb|500px|NADH Dehydrogenase Mechanism: 
1. The seven primary iron sulfur centers serve to carry electrons from the site of NADH dehydration to ubiquinone. Note that N7 is not found in eukaryotes.

2. There is a reduction of ubiquinone (CoQ) to ubiquinol (CoQH<sub>2</sub>).

3. The energy from the redox reaction results in conformational change allowing hydrogen ions to pass through four transmembrane helix channels.
]]

'''Respiratory complex I''', {{EC number|7.1.1.2}} (also known as '''NADH:ubiquinone oxidoreductase''', '''Type I NADH dehydrogenase''' and '''mitochondrial complex I''') is the first large [[protein complex]] of the [[Electron transport chain|respiratory chain]]s of many organisms from bacteria to humans. It catalyzes the transfer of [[electron]]s from [[NADH]] to [[coenzyme Q10]] (CoQ10) and translocates protons across the inner [[mitochondria]]l membrane in eukaryotes or the plasma membrane of bacteria.

{{Infobox protein family
| Symbol = Respiratory complex I
| Name = Respiratory complex I
| image = 
| width =
| caption = 
| InterPro= 
| PROSITE = 
| SCOP = 
| TCDB =
| OPM family= 246
| OPM protein= 6g72
| Pfam= 
| PDB=
| Membranome superfamily= 255
}}

{{infobox enzyme
| Name      = NADH:ubiquinone reductase (H<sup>+</sup>-translocating).
| EC_number = 7.1.1.2
| GO_code   = 0008137
|name=|CAS_number=}}

This enzyme is essential for the normal functioning of cells, and mutations in its subunits lead to a wide range of inherited neuromuscular and metabolic disorders. Defects in this enzyme are responsible for the development of several pathological processes such as [[Reperfusion injury|ischemia/reperfusion]] damage ([[stroke]] and [[Myocardial infarction|cardiac infarction]]), Parkinson's disease and others.{{Citation needed|date=May 2023}}