Editing SDHD (section)

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{{short description|Protein-coding gene in the species Homo sapiens}}
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{{Infobox gene}}

'''Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial''' (CybS), also known as '''succinate dehydrogenase complex subunit D''' (SDHD), is a [[protein]] that in humans is encoded by the ''SDHD'' [[gene]]. Names previously used for SDHD were '''PGL''' and '''PGL1'''. Succinate dehydrogenase is an important [[enzyme]] in both the [[citric acid cycle]] and the [[electron transport chain]].<ref name="entrez">{{cite web | title = Entrez Gene: succinate dehydrogenase complex| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6392}}</ref><ref name="pmid1301144">{{cite journal | vauthors = Heutink P, van der Mey AG, Sandkuijl LA, van Gils AP, Bardoel A, Breedveld GJ, van Vliet M, van Ommen GJ, Cornelisse CJ, Oostra BA | title = A gene subject to genomic imprinting and responsible for hereditary paragangliomas maps to chromosome 11q23-qter | journal = Human Molecular Genetics | volume = 1 | issue = 1 | pages = 7–10 | date = April 1992 | pmid = 1301144 | doi = 10.1093/hmg/1.1.7 }}</ref><ref name="pmid9533030">{{cite journal | vauthors = Hirawake H, Taniwaki M, Tamura A, Kojima S, Kita K | title = Cytochrome b in human complex II (succinate-ubiquinone oxidoreductase): cDNA cloning of the components in liver mitochondria and chromosome assignment of the genes for the large (SDHC) and small (SDHD) subunits to 1q21 and 11q23 | journal = Cytogenetics and Cell Genetics | volume = 79 | issue = 1–2 | pages = 132–8 | year = 1997 | pmid = 9533030 | doi = 10.1159/000134700 }}</ref> Hereditary PGL-PCC syndrome is caused by a parental imprint of the SDHD gene. Screening can begin by 6 years of age.