Editing SOS response (section)

{{Short description|Cell response to DNA damage}}
[[File:MMG_301_Final_Draft.png|thumb|350px|upright|right|''E. coli'' SOS System: DNA can be damaged by cross-linking agents, UV irradiation, alkylating agents, etc. Once damaged, RecA, a LexA protease, senses that damaged DNA and becomes activated by removing its repressor. Once the LexA dimer repressor is removed, the expression of LexA operon is autoregulatory. In addition to being a LexA protease, the RecA protein also catalyzes a few novel DNA reactions such as annealing of single-stranded DNA and transfer of strands. The SOS system has enhanced DNA-repair capacity, including excision and post-replication repair, enhanced mutagenesis and prophage induction. The system can also inhibit cell division and cell respiration.<ref>{{cite journal |last1=Little |first1=John W. |last2=Mount |first2=David W. |title=The SOS regulatory system of Escherichia coli |journal=Cell |date=May 1982 |volume=29 |issue=1 |pages=11–22 |doi=10.1016/0092-8674(82)90085-X |pmid=7049397|s2cid=12476812}}</ref>]] 
[[Image:SOS response antibiotic resistance.png|thumb|200px|upright|right|The SOS response has been proposed as a model for [[bacterial phylodynamics|bacterial evolution]] of certain types of [[antibiotic resistance]].<ref>{{cite journal |last1=Michel |first1=Bénédicte |title=After 30 Years of Study, the Bacterial SOS Response Still Surprises Us |journal=PLOS Biology |date=12 July 2005 |volume=3 |issue=7 |pages=e255 |doi=10.1371/journal.pbio.0030255 |pmid=16000023 |pmc=1174825 |doi-access=free}}</ref>]]
The '''SOS response''' is a global transcriptional response to [[DNA]] damage in [[prokaryote]]s, in which the [[cell cycle]] is arrested and [[DNA repair]] mechanisms (error-free as well as error-prone) are induced. The regulation of this response is driven by two proteins, [[RecA]] and [[LexA]]. The RecA protein, stimulated by single-stranded DNA, is involved in the inactivation of the repressor ([[LexA]]) of SOS response genes thereby inducing the response. It is an error-prone repair system that contributes significantly to DNA changes observed in a wide range of bacterial species.