Editing Serotonin transporter (section)

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{{Short description|Mammalian protein found in humans}}
{{Use dmy dates|date=March 2014}}
{{Infobox gene}}
The '''serotonin transporter''' ('''SERT''' or '''5-HTT''') also known as the '''sodium-dependent serotonin transporter''' and '''solute carrier family 6 member 4''' is a [[protein]] that in humans is encoded by the '''SLC6A4''' [[gene]].<ref>{{cite web | title = SLC6A4 Gene (Protein Coding) | url = https://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC6A4}}</ref> SERT is a type of [[monoamine transporter]] [[protein]] that transports the [[neurotransmitter]] [[serotonin]] from the [[synaptic cleft]] back to the [[presynaptic neuron]], in a process known as serotonin [[reuptake]].<ref>{{cite web | title = SLC6A4 - Sodium-dependent serotonin transporter - Homo sapiens (Human) - SLC6A4 gene & protein | url = https://www.uniprot.org/uniprot/P31645}}</ref>

This transport of serotonin by the SERT protein terminates the action of serotonin and recycles it in a sodium-dependent manner. Many antidepressant medications of the [[SSRI]] and [[tricyclic antidepressant]] classes work by binding to SERT and thus reducing serotonin reuptake.<ref name="Squire2008">{{cite book | veditors = Squire L, Berg D, Bloom FE, du Lac S, Ghosh A, Spitzer NC |title=Fundamental neuroscience |year=2008 |publisher=Elsevier / Academic Press |location=Amsterdam |isbn=978-0-12-374019-9 |pages=143 |edition=3rd }}</ref> It is a member of the [[sodium:neurotransmitter symporter]] family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in [[sudden infant death syndrome]], aggressive behavior in [[Alzheimer disease]] patients, [[post-traumatic stress disorder]] and depression-susceptibility in people experiencing emotional trauma.<ref>{{cite web | title = Entrez Gene: SLC6A4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6532}}</ref>