Editing Sup35p (section)

{{More citations needed|date=December 2009}}
{{Infobox nonhuman protein
| Name = Eukaryotic peptide chain release factor GTP-binding subunit
| image =
| width =
| caption =
| Organism = Saccharomyces cerevisiae strain S288c
| TaxID = 559292
| Symbol = Sus35
| AltSymbols =
| EntrezGene = 851752
| HomoloGene = 68226
| PDB =
| RefSeqmRNA = NM_001180479.3
| RefSeqProtein = NP_010457.3
| UniProt = P05453
| ECnumber =
| Chromosome = IV
| EntrezChromosome = NC_001136.10
| GenLoc_start = 808014
| GenLoc_end = 810689
}}
'''Sup35p''' is the ''[[Saccharomyces cerevisiae]]'' (a [[yeast]]) [[eukaryotic]] [[translation (genetics)|translation]] [[release factor]]. More specifically, it is the yeast eukaryotic [[release factor]] 3 (eRF3), which forms the translation termination complex with eRF1 ([[Sup45p]] in yeast). This complex recognizes and catalyzes the release of the nascent polypeptide chain when the [[ribosome]] encounters a [[stop codon]]. While eRF1 recognizes stop codons, eRF3 facilitates the release of the polypeptide chain through GTP hydrolysis.

Partial loss of function results in nonsense suppression, in which stop codons are ignored and [[protein]]s are abnormally synthesized with [[carboxyl]] terminal extensions. Complete loss of function is fatal.