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Synaptic vesicle
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{{Short description|Neurotransmitters that are released at the synapse}} {{Infobox microanatomy | Name = Synaptic vesicle | Latin = vesicula synaptica | Image = Synapse diag1.svg | Caption = Neuron '''A''' (transmitting) to neuron '''B''' (receiving).<br />'''1'''. [[Mitochondrion]];<br /> '''2'''. Synaptic vesicle with [[neurotransmitters]];<br />'''3'''. Autoreceptor<br />'''4'''. [[Synapse]] with neurotransmitter released ([[serotonin]]);<br />'''5'''. Postsynaptic receptors activated by neurotransmitter (induction of a [[postsynaptic potential]]);<br />'''6'''. [[Calcium channel]];<br />'''7'''. [[Exocytosis]] of a vesicle;<br />'''8'''. Recaptured neurotransmitter. | Width = | Image2 = | Caption2 = | System = [[Nervous system]] }} [[File:A-dynamin-1--dynamin-3--and-clathrin-independent-pathway-of-synaptic-vesicle-recycling-mediated-by-elife01621fs001.jpg| thumb|220x124px | right]] In a [[neuron]], '''synaptic vesicles''' (or '''neurotransmitter vesicles''') store various [[neurotransmitter]]s that are [[exocytosis|released]] at the [[chemical synapse|synapse]]. The release is regulated by a [[voltage-dependent calcium channel]]. [[Vesicle (biology)|Vesicles]] are essential for propagating [[nerve impulse]]s between neurons and are constantly recreated by the [[cell (biology)|cell]]. The area in the [[axon]] that holds groups of vesicles is an [[axon terminal]] or "terminal bouton". Up to 130 vesicles can be released per bouton over a ten-minute period of stimulation at 0.2 Hz.<ref name="count09">{{cite journal | last1 = Ikeda | first1 = K | last2 = Bekkers | first2 = JM | year = 2009 | title = Counting the number of releasable synaptic vesicles in a presynaptic terminal | journal = Proc Natl Acad Sci U S A | volume = 106 | issue = 8| pages = 2945β50 | doi = 10.1073/pnas.0811017106 | pmid = 19202060 | pmc=2650301| bibcode = 2009PNAS..106.2945I | doi-access = free }}</ref> In the [[visual cortex]] of the human brain, synaptic vesicles have an average diameter of 39.5 [[nanometer]]s (nm) with a standard deviation of 5.1 nm.<ref name="Qu_2009">{{cite journal|last1=Qu|first1=Lei|last2=Akbergenova|first2=Yulia|last3=Hu|first3=Yunming|last4=Schikorski|first4=Thomas|title=Synapse-to-synapse variation in mean synaptic vesicle size and its relationship with synaptic morphology and function|journal=The Journal of Comparative Neurology|date=March 2009|volume=514|issue=4|pages=343β352|doi=10.1002/cne.22007 |url=http://www3.interscience.wiley.com/journal/122264646/abstract|archive-url=https://archive.today/20130105080437/http://www3.interscience.wiley.com/journal/122264646/abstract|url-status=dead|archive-date=2013-01-05|pmid=19330815|s2cid=23965024|url-access=subscription}}</ref>
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