Editing Transactivation (section)

In the context of gene regulation: '''transactivation''' is the increased rate of [[gene expression]] triggered either by biological processes or by artificial means, through the expression of an intermediate transactivator protein.  

In the context of receptor signaling, '''transactivation''' occurs when one or more receptors activate yet another;<ref name="Receptor transactivation">{{cite web|title=receptor transactivation|url=http://www.ebi.ac.uk/QuickGO/GTerm?id=GO:0035624|website=EMBL|publisher= GO Consortium|access-date=6 April 2015}}</ref><ref name="DA receptor 2015">{{cite journal | vauthors = Beaulieu JM, Espinoza S, Gainetdinov RR | title = Dopamine receptors - IUPHAR Review 13 | journal = Br. J. Pharmacol. | volume = 172 | issue = 1 | pages = 1–23 | date = January 2015 | pmid = 25671228 | pmc = 4280963 | doi = 10.1111/bph.12906 | quote = For instance,there are indications that both D1 and D2 receptors can trans-activate the brain-derived neurotrophic factor (BDNF) receptor in neurons (Swift et al., 2011). These two dopamine receptors can also regulate calcium channels through a direct protein–protein interaction in vivo (Kisilevsky and Zamponi, 2008; Kisilevsky et al., 2008). Direct interaction of D1 and D2 receptors and Na+-K+-ATPase has also been demonstrated (Hazelwood et al., 2008; Blom et al., 2012).}}</ref> receptor transactivation may result from the [[Crosstalk (biology)|crosstalk]] of [[signaling cascade]]s or the activation of [[GPCR oligomer|G protein–coupled receptor hetero-oligomer]] subunits, among other mechanisms.<ref name="Receptor transactivation" />