Open main menu
Home
Random
Recent changes
Special pages
Community portal
Preferences
About Wikipedia
Disclaimers
Incubator escapee wiki
Search
User menu
Talk
Dark mode
Contributions
Create account
Log in
Editing
Tuinal
(section)
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
{{Short description|Combination drug}} {{Infobox drug | INN = none | drug_name = Secobarbital/amobarbital | type = combo <!-- Combo data -->| component1 = Secobarbital | class1 = Short-acting [[barbiturate]] | component2 = Amobarbital | class2 = Short- to intermediate-acting [[barbiturate]] | image = Secobarbital and amobarbital.svg | image_class = skin-invert-image | pronounce = | tradename = Tuinal | Drugs.com = | MedlinePlus = | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> | pregnancy_AU_comment = | pregnancy_category = | routes_of_administration = [[Oral administration|By mouth]] | ATCvet = | ATC_prefix = <!-- 'none' if uncategorised --> | ATC_suffix = <!-- Legal status --> | legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled --> | legal_AU_comment = | legal_BR = <!-- OTC, A1, A2, A3, B1, B2, C1, C2, C3, C4, C5, D1, D2, E, F --> | legal_BR_comment = | legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII --> | legal_CA_comment = | legal_DE = <!-- Anlage I, II, III or Unscheduled --> | legal_DE_comment = | legal_NZ = <!-- Class A, B, C --> | legal_NZ_comment = | legal_UK = <!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD (Benz) POM, CD (Anab) POM or CD Inv POM / Class A, B, C --> | legal_UK_comment = | legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> | legal_US_comment = Schedule II | legal_EU = | legal_EU_comment = | legal_UN = <!-- N I, II, III, IV / P I, II, III, IV --> | legal_UN_comment = | legal_status = <!-- For countries not listed above --> <!-- Identifiers -->| CAS_number = 8065-05-2 | PubChem = 3080650 | DrugBank = | KEGG = | StdInChI = 1S/C12H18N2O3.C11H18N2O3.2Na/c1-4-6-8(3)12(7-5-2)9(15)13-11(17)14-10(12)16;1-4-11(6-5-7(2)3)8(14)12-10(16)13-9(11)15;;/h5,8H,2,4,6-7H2,1,3H3,(H2,13,14,15,16,17);7H,4-6H2,1-3H3,(H2,12,13,14,15,16);;/q;;2*+1/p-2 | StdInChIKey = HQBIOVWPIHUNKN-UHFFFAOYSA-L | SMILES = CCCC(C)C1(C(=O)NC(=O)N=C1[O-])CC=C.CCC1(C(=O)NC(=O)N=C1[O-])CCC(C)C.[Na+].[Na+] }} '''Tuinal''' was the brand name of a discontinued [[combination drug]] composed of two [[barbiturate]] sodium salts ([[secobarbital]] and [[amobarbital]]) in equal proportions. Tuinal was introduced as a [[sedative]]-[[hypnotic]] (sleeping pill) [[medication]] in the late 1940s by [[Eli Lilly and Company|Eli Lilly]]. It was also used in [[obstetrics]] for [[childbirth]].<ref>{{Cite journal | vauthors = Waters AB |date=1947 |title=Pethidine In Labour | jstor = 20370143 |journal=The British Medical Journal |volume=2 |issue=4514 |pages=71β72 |doi=10.1136/bmj.2.4514.71-b |pmid=20344014 |pmc=2055200 |issn=0007-1447}}</ref><ref>{{Cite journal |date=1948 |title=Front Matter | jstor = 25361874 |journal=The British Medical Journal |volume=1 |issue=4539 |issn=0007-1447}}</ref> It was produced in brightly colored half-reddish orange and half-turquoise blue [[capsule (pharmacy)|gelatin capsule]] form (bullet-shaped Pulvules) for [[oral administration]]. Individual capsules contained 50 mg, 100 mg, or 200 mg of barbiturate salts. The combination of a short-acting barbiturate, secobarbital, with an intermediate-acting barbiturate, amobarbital, aimed to provide "a rapid yet prolonged hypnotic action".<ref>{{Cite journal |date=1947 |title=Front Matter |journal=The American Journal of Nursing |volume=47 |issue=5 |pages=1β24 | jstor = 3457169 |issn=0002-936X}}</ref> Eli Lilly has discontinued the manufacture of Tuinal in the United States due to the diminishing use of barbiturates (largely replaced by the [[benzodiazepine]] family of drugs) in outpatient treatment, and its widespread [[Substance abuse|abuse]].<ref>{{cite book | vauthors = Mitchell M, Willingham EJ, Atkins WA | veditors = Key K |date=2012 |title=The Gale Encyclopedia of Mental Health |edition=3rd |volume=1 |url= https://link.gale.com/apps/doc/CX4013200056/GVRL?u=rock21695&sid=bookmark-GVRL&xid=0b9d1be5 |access-date=November 4, 2022 |location=Detroit, MI |publisher=Gale eBooks |page=171 |isbn=9781414490144 |url-access=subscription}}</ref> Currently, Valleant Labs markets secobarbital capsules only. Flynn Pharma of Ireland no longer manufactures Tuinal, Seconal (secobarbital), or Amytal (amobarbital). Amytal has been discontinued, though [[Injection (medicine)|injectable]] forms of amobarbital sodium remain. The drug was featured in "Psycho Therapy," a song by the musical band Ramones, who stated "I like takin' Tuinal/It keeps me edgy and mean/I'm a teenage schizoid/I'm a teenage dope fiend." It is also mentioned in "Lost Johnny" a song by the band Hawkwind in the last verse, "And we're all taking Tuinal/to murder our young dreams." Most famously, Tuinal is mentioned by Shane MacGowan in the song "Old Main Drag" by The Pogues.
Edit summary
(Briefly describe your changes)
By publishing changes, you agree to the
Terms of Use
, and you irrevocably agree to release your contribution under the
CC BY-SA 4.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)