Editing 2C-B (section)

==Use==
===Recreational===
[[File:4-bromo-2,5-dimethoxyphenethylamine.jpg|1000mg of 2C-B|thumb|right]]

2C-B became briefly popular in the United States as substitute for the street drug [[MDMA|ecstasy]] (MDMA) when the latter became illegal in 1985.<ref name=Colombia>{{cite news | vauthors = Pachico E |title=2CB Now Drug of Choice for Colombia Elite|url=http://www.insightcrime.org/news-analysis/2c-b-now-drug-of-choice-for-colombia-elite|access-date=11 February 2013|newspaper=InSight Crime|date=1 November 2012}}</ref> Many 2C-B users are young adults who attend [[rave]]s.<ref name="DEA - Evaluation Section" /> Although 2C-B is still used in the rave subculture (commonly mistaken for and/or sold as ecstasy), more knowledgeable use has become more widespread in the 2000s.<ref name="Gahlinger book">{{cite book| vauthors = Gahlinger P |title=Illegal Drugs: A Complete Guide to Their History, Chemistry, Use and Abuse|year=2004|publisher=Penguin|isbn=9780452285057|pages=343–344|url=https://books.google.com/books?id=kPszgXPVQAsC&pg=PT463}}</ref>

===Entheogenic===
There are claims that 2C-B was used as [[entheogen]] by the [[Sangoma]], [[Nyanga people|Nyanga]], and [[Xhosa people#Folklore and religion|Amagqirha]] people in place of their traditional plants; they refer to the chemical as ''Ubulawu Nomathotholo'', which roughly translates to "''Medicine of the Singing Ancestors''".<ref>{{cite web |date=2008-03-27 |title=2CB chosen over traditional entheogen's by South African healers. |url=http://www.tacethno.com/info/2cb/2cbhistory.html#South%20Africa |access-date=May 15, 2012 |publisher=Tacethno.com}}</ref><ref>[http://www.erowid.org/chemicals/2cb/2cb_article1.shtml The Nexus Factor - An Introduction to 2C-B] Erowid</ref><ref>[http://www.erowid.org/chemicals/show_image.php?i=2cb/ubulawu_pack.jpg Ubulawu Nomathotholo Pack] Photo by Erowid. © 2002 Erowid.org</ref>

===Dosage===
In Shulgin's book ''[[PiHKAL]]'', the oral dosage range is listed as 12 to 24{{nbsp}}mg.<ref name="PiHKAL">{{Cite book |url=https://www.worldcat.org/oclc/25627628 |title=Pihkal : a chemical love story |vauthors=Shulgin AT |date=1991 |publisher=Transform Press |others=Ann Shulgin |isbn=0-9630096-0-5 |location=Berkeley, CA |oclc=25627628}}</ref> The common oral recreational dose per [[Erowid]] is around 15 to 25{{nbsp}}mg.<ref name="urlErowid 2C-B Vault : Dose/Dosage">{{cite web |title=Erowid 2C-B Vault : Dose/Dosage |url=http://www.erowid.org/chemicals/2cb/2cb_dose.shtml}}</ref> Shulgin and others describe 2C-B as having a steep [[dose–response curve]], such that a small increase in dose can result in an unexpectedly large increase in effects.<ref name="PiHKAL" /><ref name="PalamarAcosta2020" />

{| class="wikitable"
|+ 2C-B dosage{{Citation needed|date=May 2025}}
|-
! |
! width="100px" | Oral
! width="120px" | Insufflated
|-
| [[Effective dose (pharmacology)|ED<sub>50</sub>]] || 10&nbsp;mg || 4–6&nbsp;mg
|-
| Moderate || 15–25&nbsp;mg || 5–9&nbsp;mg
|-
| Strong || 26–35&nbsp;mg || 10–20&nbsp;mg
|-
| Extremely Intense || >35&nbsp;mg || >20&nbsp;mg
|-
| Duration || 4–8 hours || 2–4 hours
|}

When sold as "Ecstasy", tablets containing 2C-B often contain about 5&nbsp;mg of the drug, an amount which produces stimulatory effects that mimic the effects of MDMA; in contrast, tablets marketed as 2C-B have larger quantities of the drug (10–20&nbsp;mg) which cause [[hallucinogen]]ic effects.<ref name="Netherlands 2c-b emergence">{{cite journal |vauthors=de Boer D, Gijzels MJ, Bosman IJ, Maes RA |year=1999 |title=More data about the new psychoactive drug 2C-B |journal=Journal of Analytical Toxicology |volume=23 |issue=3 |pages=227–8 |doi=10.1093/jat/23.3.227 |pmid=10369336 |doi-access=free}}</ref>

===Duration===
When [[Oral administration|orally]] consumed, 2C-B has a much longer delay before the onset of effects than when it is insufflated. Oral ingestion generally takes roughly 45–75 minutes for the effects to be felt, plateau lasts 2–4 hours, and coming down lasts 1–2 hours. [[Rectal administration]] onset varies from 5 to 20 minutes. Insufflated onset takes 1–10 minutes for effects to be felt. The duration can last from 4 to 12 hours depending on route of administration, dose, and other factors.<ref name="erowid effects"/>

With insufflation, the effects are more abrupt and intense but have a significantly shorter duration, while oral usage results in a milder, longer experience. When insufflated, the onset happens very rapidly, usually reaching the peak at about 20–40 minutes and plateauing for 2–3 hours. 2C-B is also considered one of the most painful drugs to insufflate, with users reporting intense nasal burning.<ref name="erowid basics"/> The sudden intensity of the experience combined with the pain can often start the experience with a negative imprint and nausea is also increased with insufflation, compounding the issue.