Editing 4-Hydroxynonenal (section)

==Synthesis==
4-Hydroxynonenal is generated in the oxidation of [[lipid]]s containing [[polyunsaturated]] [[Omega-6 fatty acid|omega-6 fatty acids]], such as [[arachidonic]] and [[Linoleic acid|linoleic acids]], and of their 15-lipoxygenase metabolites, namely [[15-hydroxyeicosatetraenoic acid|15-hydroperoxyeicosatetraenoic]] and [[13-hydroxyoctadecadienoic acid|13-hydroperoxyoctadecadienoic acids]].<ref>{{Cite journal | doi = 10.1152/ajpendo.00508.2010| title = Signaling and cytotoxic functions of 4-hydroxyalkenals| journal = AJP: Endocrinology and Metabolism| volume = 299| issue = 6| pages = E879-86| year = 2010| last1 = Riahi| first1 = Y.| last2 = Cohen| first2 = G.| last3 = Shamni| first3 = O.| last4 = Sasson| first4 = S.| s2cid = 6062445| pmid=20858748}}</ref> Although they are the most studied ones, in the same process other oxygenated α,β-unsaturated [[aldehyde]]s (OαβUAs) are generated also, which can also come from omega-3 fatty acids, such as 4-oxo-trans-2-nonenal, 4-hydroxy-trans-2-hexenal, 4-hydroperoxy-trans-2-nonenal and [[Trans-4,5-Epoxy-(E)-2-decenal|4,5-epoxy-''trans''-2-decenal]].