Editing 5-Hydroxytryptophan (section)

==Production==
5-HTP is produced from the amino acid [[tryptophan]] through the action of the enzyme [[tryptophan hydroxylase]]. Tryptophan hydroxylase is one of the [[biopterin-dependent aromatic amino acid hydroxylases]]. Production of 5-HTP is the rate-limiting step in 5-HT (serotonin)  synthesis. 5-HTP is normally rapidly converted to 5-HT by amino acid decarboxylase.<ref name="TurnerLoftisBlackwell2006">{{cite journal | vauthors = Turner EH, Loftis JM, Blackwell AD | title = Serotonin a la carte: supplementation with the serotonin precursor 5-hydroxytryptophan | journal = Pharmacology & Therapeutics | volume = 109 | issue = 3 | pages = 325–338 | date = March 2006 | pmid = 16023217 | doi = 10.1016/j.pharmthera.2005.06.004 | s2cid = 2563606 | url = https://escholarship.org/uc/item/58h866d5 | quote = 5-HTP is commonly given to rats or mice to test the SSRI potency of putative antidepressants (O’Neil & Moore, 2003). This simple in vivo test measures the potency of a compound in potentiating the serotonin syndrome induced by the administration of 5-HTP (Grahame-Smith, 1971). The behavioral and physiological features of this syndrome include hypolocomotion, head twitch, forepaw treading, tremors, hindlimb abduction, flat body posture or hunched back, cyanosis, and hyperthermia. In rodents, 5-HTP induces a serotonin syndrome at dosages of 100– 200 mg/ kg (Casal et al., 2000; Nisijima et al., 2000, 2001; see Section 4.4.3 for more on serotonin syndrome).}}</ref>