Editing Adiponectin (section)

== Structure  ==
Adiponectin is a 244-amino-acid-long polypeptide [[Hormone#Animal|(protein)]]. It has four distinct regions: The first is a short signal sequence that targets the hormone for secretion outside the cell; next is a short region that varies between species; the third is a 65-amino acid region with similarity to collagenous proteins; the last is a globular domain. Overall, this protein shows similarity to the complement 1Q factors ([[C1q|C1Q]]), but when the three-dimensional structure of the globular region was determined, a striking similarity to [[Tumor necrosis factor-alpha|TNFα]] was observed, despite unrelated protein sequences.<ref name="pmid9512423">{{cite journal | vauthors = Shapiro L, Scherer PE | title = The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor | journal = Current Biology | volume = 8 | issue = 6 | pages = 335–338 | date = March 1998 | pmid = 9512423 | doi = 10.1016/S0960-9822(98)70133-2 | s2cid = 14287212 | doi-access = free | bibcode = 1998CBio....8..335S }}</ref>