Editing Amyl nitrite (section)

==Uses==
* Amyl nitrite was historically employed medically to treat [[ischaemic heart disease|heart disease]]s as well as [[Angina pectoris|angina.]] 
* Amyl nitrite was sometimes used as an antidote for [[cyanide poisoning]].<ref name="detoxification48"/><ref>{{cite journal | vauthors = Mason DT, Braunwald E | title = The effects of nitroglycerin and amyl nitrite on arteriolar and venous tone in the human forearm | journal = Circulation | volume = 32 | issue = 5 | pages = 755–766 | date = November 1965 | pmid = 4954412 | doi = 10.1161/01.cir.32.5.755 | doi-access = free }}</ref> It was thought to act as an [[oxidant]], to induce the formation of [[methemoglobin]]. [[Methemoglobin]] in turn can sequester [[cyanide]] as cyanomethemoglobin.<ref>{{cite journal| title = Cyanide Antidotes: from Amyl Nitrite to Hydroxocobalamin – Which Antidote is Best?| vauthors = Vale JA | journal = [[Toxicology (journal)|Toxicology]]| year = 2001| volume = 168| issue = 1| pages = 37–38}}</ref> However, it has been replaced by [[hydroxocobalamin]] which had better efficacy,<ref>{{cite journal| vauthors = Hall AH, Saiers J, Baud F | title = Which cyanide antidote? | journal = Crit Rev Toxicol | date = 2009 | volume = 39 | issue = 7 | pages = 541–552 | pmid =  19650716| doi = 10.1080/10408440802304944 | doi-access = free }}</ref> and the use of amyl nitrite has been found to be ineffective and unscientific.<ref>{{cite journal| vauthors = Lavon O, Bentur Y | title = Does amyl nitrite have a role in the management of pre-hospital mass casualty cyanide poisoning? | journal = Clin Toxicol (Phila) | volume = 48 | issue = 6 | pages = 477–484 | date = July 2010 | pmid =  20653465| doi = 10.3109/15563650.2010.505573 | doi-access = free }}</ref>
*  Trace amounts are added to some [[perfumes]].<ref>{{cite web |url= https://pubchem.ncbi.nlm.nih.gov/compound/Amyl-nitrite#section=Use-and-Manufacturing |title=Amyl Nitrite Use and Manufacturing|work=PubChem | publisher = U.S. National Library of Medicine }}</ref>
* It is also used recreationally as an [[inhalant]] drug that induces a brief euphoric state, and when combined with other intoxicant stimulant drugs such as [[cocaine]] or [[MDMA]], the euphoric state intensifies and is prolonged. Once some stimulative drugs wear off, a common side effect is a period of [[Depression (mood)|depression]] or [[anxiety (mood)|anxiety]], colloquially called a "come down"; amyl nitrite is sometimes used to combat these negative after-effects. {{Citation needed|date=May 2025}}  This effect, combined with its dissociative effects, has led to its use as a recreational drug {{xref|(see: [[Poppers]])}}.<ref name="detoxification48">{{cite book | vauthors = Giannini AJ, Slaby AE, Giannini MC | title = The Handbook of Overdose and Detoxification Emergencies | location = New Hyde Park, NY. | publisher = Medical Examination Publishing Co. | date = 1982 | pages = 48–50 }}</ref>