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Anaphylatoxin
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== Function == Anaphylatoxins are able to trigger [[degranulation]] (release of substances) of [[endothelial cells]], [[mast cells]] or [[phagocytes]], which produce a local inflammatory response. If the degranulation is widespread, it can cause a shock-like syndrome similar to that of an [[allergic reaction]]. Anaphylatoxins indirectly mediate: * [[smooth muscle|smooth muscle cells]] contraction, for example [[bronchospasm]]s * increase in the permeability of [[capillary|blood capillaries]] * C5a indirectly mediates [[chemotaxis]]—[[receptor (biochemistry)|receptor]]-mediated movement of [[leukocyte]]s in the direction of the increasing concentration of anaphylatoxins
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