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==History== Used on a short-term basis clinically to treat [[obesity]], some appetite suppressants are also available [[over-the-counter drug|over-the-counter]]. Several appetite suppressants are based on a mix of natural ingredients, mostly using green tea as its basis, in combination with other plant extracts, such as [[fucoxanthin]], found naturally in seaweed. [[Medication|Drugs]] of this class are frequently [[stimulant]]s of the [[phenethylamine]] family, related to [[amphetamine]].<ref>{{Cite web |date=2025-04-27 |title=Fucoxanthin Benefits: 7 Powerful Health Effects You Need to Know |url=https://www.wecookrecipes.com/fucoxanthin-benefits/ |access-date=2025-04-27 |website=www.wecookrecipes.com |language=en-US}}</ref> The German and Finnish<ref name=Pervitine>[[:fi:Pervitiini]]</ref> militaries issued amphetamines ([[Methamphetamine|Pervitin]]) to soldiers commonly during the [[Second World War]].<ref name=military-use>{{cite news |date=May 6, 2005 |url=http://www.spiegel.de/international/0,1518,354606,00.html |title=The Nazi Death Machine: Hitler's Drugged Soldiers |access-date=2011-01-05 |last=Ulrich |first=Andreas |work=Spiegel Online }}</ref> Similarly, the [[British Armed Forces|UK military]] was supplied with more than 72 million [[Amphetamine|Benzedrine]] tablets and the [[United States Armed Forces|US military]] with an approximately equal amount for situations, in which fatigue was not deemed to be an acceptable option.<ref>{{Cite journal |last=Bett |first=W. R. |date=1946-08-01 |title=Benzedrine Sulphate in Clinical Medicine |journal=Postgraduate Medical Journal |language=en |volume=22 |issue=250 |pages=215 |doi=10.1136/pgmj.22.250.205 |issn=0032-5473 |pmc=2478360 |pmid=20997404}}</ref> Following the war, large amphetamine surpluses were redirected for use on the black<ref>{{Cite journal |last1=Heal |first1=David J |last2=Smith |first2=Sharon L |last3=Gosden |first3=Jane |last4=Nutt |first4=David J |date=June 2013 |title=Amphetamine, past and present – a pharmacological and clinical perspective |journal=Journal of Psychopharmacology |language=en |volume=27 |issue=6 |pages=486 |doi=10.1177/0269881113482532 |issn=0269-8811 |pmc=3666194 |pmid=23539642 }}</ref> and the civilian market. Indeed, amphetamine itself was sold commercially as an appetite suppressant until it was outlawed in most parts of the world in the late 1950s because of safety issues. Many amphetamines produce side effects, including [[Substance dependence|addiction]], [[tachycardia]] and [[hypertension]],<ref>{{cite journal |doi=10.1056/NEJM199608293350901 |pmid=8692238 |title=Appetite-Suppressant Drugs and the Risk of Primary Pulmonary Hypertension |journal=New England Journal of Medicine |volume=335 |issue=9 |pages=609–16 |year=1996 |last1=Abenhaim |first1=Lucien |last2=Moride |first2=Yola |last3=Brenot |first3=François |last4=Rich |first4=Stuart |last5=Benichou |first5=Jacques |last6=Kurz |first6=Xavier |last7=Higenbottam |first7=Tim |last8=Oakley |first8=Celia |last9=Wouters |first9=Emil |last10=Aubier |first10=Michel |last11=Simonneau |first11=Gérald |last12=Bégaud |first12=Bernard |doi-access=free }}</ref> making prolonged unsupervised use dangerous.
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